Multi-stimuli-responsive degradable boronic ester-crosslinked e-spun nanofiber wound dressings
Bibliographic record
Abstract
value, is proved to be an effective crosslinker to fabricate BE-crosslinked PVA e-spun nanofibrous materials. In response to multiple stimuli such as reactive oxygen species, alkaline pH, and glucose (common features of wounds), the fibers degrade through the cleavage of BE bonds or transesterification, confirmed by our model spectroscopic study with a small molecular boronic ester. Such wound-induced degradation ensures the controlled/enhanced release of antibiotics active against both Gram-positive and Gram-negative bacteria. These results, combined with their non-hemolysis and non-cytotoxicity properties, demonstrate that the approach is versatile for the fabrication of well-defined BE-crosslinked PVA e-spun nanofibers that are dimensionally stable but degrade to release antibiotics in wounds, thus exhibiting a great promise as smart wound dressing materials.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".