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Record W4411110839 · doi:10.1007/s00586-025-08997-5

Endplate preparation for anterior cervical discectomy and fusion: does the amount of endplate removed affect cage subsidence risk?

2025· article· en· W4411110839 on OpenAlexaff
Alick Wang, Thomas A Slater, Kay A. Raftery, Spyros D. Masouros, Hannah A. Levy, Brett A. Freedman, Nicolas Newell

Bibliographic record

VenueEuropean Spine Journal · 2025
Typearticle
Languageen
FieldMedicine
TopicCervical and Thoracic Myelopathy
Canadian institutionsUniversity of Ottawa
FundersEngineering and Physical Sciences Research Council
KeywordsMedicineCadaveric spasmCageAnterior cervical discectomy and fusionDiscectomySurgeryAnatomyLumbarCervical spine

Abstract

fetched live from OpenAlex

Abstract Purpose Subsidence after anterior cervical discectomy and fusion (ACDF) is a common complication that may be influenced by the degree of endplate removal prior to cage insertion. The optimal degree of endplate removal remains unclear; therefore, we performed a series of ex vivo experiments to elucidate the relationship between the aggressiveness of endplate preparation and subsidence risk. Methods Human cadaveric subaxial cervical endplates were partially decorticated either conservatively ( n = 10) or aggressively ( n = 9). The degree of endplate removal was quantified using microCT. Subsidence was modelled by measuring the strength and stiffness of each specimen when an interbody cage was axially compressed into the endplate. Results Conservative endplate preparation resulted in less endplate removal than aggressive endplate preparation (mass: 150 vs. 301 mg, p < 0.001; volume: 47 vs. 88mm 3 , p = 0.01; thickness: 0.02 vs. 0.16 mm, p = 0.004). There was no significant difference between the two groups with respect to endplate strength (2.04 vs. 2.04kN, p = 0.99) or stiffness (2.38 vs. 2.41kN/mm, p = 0.89). Bone mineral density (BMD) was similar between the two groups (271.6 vs. 271.9 mg/cm 3 , p = 0.98) but positively correlated with endplate strength (effect size 0.68, p = 0.001). Conclusions When performing partial cervical endplate decortication, the degree of bony endplate removal did not significantly predict endplate integrity during ex vivo compression testing, but greater BMD was associated with increased strength. The degree of endplate removal should be based on individual patient factors and intraoperative findings to achieve the ideal cage-endplate interface.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.863
Threshold uncertainty score0.322

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.009
GPT teacher head0.299
Teacher spread0.290 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2025
Admission routes1
Has abstractyes

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