Acute histoplasmosis in four immunocompetent Canadian travellers to a cenote in Yucatán, Mexico
Bibliographic record
Abstract
A group of four healthy Canadian travellers visited a cenote in the Yucatán peninsula in April 2024 and subsequently developed symptomatic histoplasmosis.Diagnosis was made in the acute period with a positive urine Histoplasma antigen test in three of the cases.Two developed severe presentations and were treated with itraconazole, including a three-year-old child with disseminated disease.The sensitivity of different modalities for diagnostics depends on the timing and severity of illness, with Histoplasma urine antigen being most sensitive in early infection, serology converting 4-8 weeks following exposure and cultures generally of low sensitivity.Treatment depends on the disease manifestations and host immunologic status.Many patients have relatively mild, self-limited, influenza-like illness and the diagnosis may be overlooked.Given the number of Canadian tourists travelling to the Yucatán peninsula and the popularity of visiting cenotes, awareness of the risk of histoplasmosis associated with this exposure should be promoted.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.005 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".