Polysaccharide from natural Ophiocordyceps sinensis alleviated dextran sulfate sodium-induced colitis through modulating sIgA formation and gut microbiota
Bibliographic record
Abstract
Polysaccharide from natural Ophiocordyceps sinensis (NCSP-50) significantly modulated the gut microbiota composition and elevated the levels of sIgA in dextran sodium sulfate (DSS)-induced colitis mice. However, the in-depth mechanism remains unknown. Therefore, this study aimed to investigate how NCSP-50 influenced sIgA formation and the role of gut microbiota in colitis mice. Results showed that administration of NCSP-50 dramatically improved the expressions of IgA, pIgR and AID, the key factors of sIgA formation in colitis mice. NCSP-50 significantly decreased the quantity of dendritic cells and mRNA expression of tlr-2 , tlr-4 and tlr-6 , april and raldh-1 , while improved the expression of vapc2 , raldh-2 and iNOS , indicating the involvement in T-cell independent pathway. NCSP-50 reduced the amount of CD4 + T cells, and adjusted the expression of nuclear transcription factors of T cells subsets and the release of IL-13, indicating the involvement in T-cell dependent pathway. In addition, fecal microbiota transplantation revealed that gut microbiota from mice administrated with NCSP-50 obviously alleviated colitis-related symptoms and increased the concentration of sIgA, whereas antibiotic cocktails treatments abolished those effects. In conclusion, NCSP-50 attenuated DSS-induced colitis through intestinal microbiota and promoting the T-cell dependent and independent sIgA secretion influenced by gut microbiota.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".