Photoredox Decarboxylative 3‐Fluoroallylation of α‐Amino Acids
Bibliographic record
Abstract
The photocatalytic decarboxylation of α‐amino acids is an effective route to α‐aminoalkyl radicals, which is also amenable to the derivatization of peptides through selective CC bond formation at the C‐terminus. It is reported that, in the presence of an iridium photocatalyst, allylic difluorides are suitable radical traps to capture α‐aminoalkyl radicals produced from α‐amino acids, ultimately amounting to a defluorinative 3‐fluoroallylation reaction. The catalytic system is applied to the derivatization of a wide breadth of N ‐protected amino acids and dipeptides in high yields, and the transformation displays great functional group tolerance. α‐Amino acids of all substitution levels at the α‐carbon led to the desired products in high yields. Post‐functionalization of the monofluoroalkene‐containing products reveals the potential to attain fluorine‐containing organic compounds of greater complexity.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".