POS0850 EFFECTS OF SINGLE AND DUAL TASK ON COGNITION AND LOWER EXTREMITY PERFORMANCE IN INDIVIDUALS WITH PRIMARY SJOGREN'S SYNDROME: A RANDOMIZED CONTROLLED TRIAL

<h2>Abstract</h2><h3>Background:</h3> Primary Sjögren's syndrome (pSS) is an autoimmune disease that is part of a neurological disorder [1]. Memory complaints are common. It is recommended to evaluate cognitive impairments even in the early stages of the disease [2]. It has been reported in the literature that individuals with pSS matched with healthy controls have low physical capacity, functional level and health-related quality of life; fatigue and pain severity are high [3]. However, there are limited studies in the literature on cognitive functions and exercise training in pSS. <h3>Objectives:</h3> This study aimed to examine the effect of telerehabilitation-based single-task and dual-task exercise training on cognitive functions and lower extremity muscle strength in individuals with pSS. <h3>Methods:</h3> A total of 19 voluntary individuals (mean age=58.68±4.15 years) with pSS were included in the study. They were diagnosed with pSS according to 2016 AECG (American-European Consensus Group) criteria and applied to Pamukkale University Faculty of Medicine, Department of Rheumatology, were included in study. The participants were randomly divided into 2 groups. The dual-task exercise training group (intervention group) had 9 participants (mean age=58.77±4.29 years), and the single-task exercise training group (control group) had 10 participants (mean age=58.60±4.24 years). After demographic and disease-related data were recorded, cognitive functions (Montreal Cognitive Assessment-MoCA), dual task assessment (The Timed Up and Go Test- TUG) and lower extremity muscle strength and endurance (30 Second Chair Stand Test-30CST) were assessed at baseline and after the intervention. All participants attended 60-min telerehabilitation-based exercise training (10-min warm up, 40-min functional exercises focused on trunk stabilization, 10-min cool down) three times a week for 8 weeks which was progressively challenged. Intervention group, combined telerehabilitation-based exercise training (functional exercises focused on trunk stabilization, including warm-up and cool-down) with cognitive task. On the other hand, in control group only telerehabilitation-based exercise training was applied. The Mann-Whitney U Test and Wilcoxon test were used to analyze the data. <h3>Results:</h3> After intervention, there were a statistically advanced level of significant improvement in dual task performance rate (p=0.001); dual task error hits (p=0.002); MoCA, TUG and 30CST (p<0.001) in the intervention group. When the delta values were compared, it was significant in favor of the intervention group (p <0.001). <h3>Conclusion:</h3> Telerehabilitation-based exercise training has a positive effect on cognition and lower extremity performance in individuals with pSS when applied together with cognitive task. <h3>REFERENCES:</h3> [1] Riega‐Torres, J. C. L., Treviño‐Castro, M. A., Hernandez‐Galarza, I. D. J., Garza‐Martinez, M. J., Vera‐Pineda, R., Cardenas‐de la Garza, J. A., & Galarza‐Delgado, D. A. (2020). Cognitive dysfunction in Sjögren's syndrome using the Montreal Cognitive Assessment Questionnaire and the Automated Neuropsychological Assessment Metrics: A cross‐sectional study. International journal of rheumatic diseases, 23(8), 1019-1023. doi: 10.1111/1756-185X.13889. [2] Manzo, C., Martinez-Suarez, E., Kechida, M., Isetta, M., & Serra-Mestres, J. (2019). Cognitive function in primary Sjögren's syndrome: a systematic review. Brain sciences, 9(4), 85. doi: 10.3390/brainsci9040085. [3] Dassouki T, Benatti FB, Pinto AJ, Roschel H, Lima FR, Augusto K, Pasoto S, Pereira RMR, Gualano B, de Sá Pinto AL. Objectively measured physical activity and its influence on physical capacity and clinical parameters in patients with primary Sjögren's syndrome. Lupus. 2017 Jun;26(7):690-697. doi: 10.1177/0961203316674819. <h3>Acknowledgements:</h3> <b>NIL</b>. <h3>Disclosure of Interests:</h3> <b>None declared</b>. © The Authors 2025. This abstract is an open access article published in Annals of Rheumatic Diseases under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Neither EULAR nor the publisher make any representation as to the accuracy of the content. The authors are solely responsible for the content in their abstract including accuracy of the facts, statements, results, conclusion, citing resources etc.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.