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Record W4411463448 · doi:10.1186/s44167-025-00079-7

Associations of physical activity, sedentary behavior, and sleep patterns with cognitive function among middle-aged and older adults

2025· article· en· W4411463448 on OpenAlexaboutno aff
Yuzi Zhang, Baojiang Chen, Emily T. Hébert, Laura F. DeFina, David Leonard, Carolyn E. Barlow, Andjelka Pavlovic, Harold W. Kohl

Bibliographic record

VenueJournal of Activity Sedentary and Sleep Behaviors · 2025
Typearticle
Languageen
FieldMedicine
TopicPhysical Activity and Health
Canadian institutionsnot available
Fundersnot available
KeywordsSittingCognitionMultinomial logistic regressionPsychologyMontreal Cognitive AssessmentGerontologyLatent class modelAssociation (psychology)DemographyMedicineCognitive impairmentPsychiatryStatistics

Abstract

fetched live from OpenAlex

BACKGROUND: Despite the established evidence that physical activity, sedentary behavior, and sleep affect cognitive function individually, less is known about the combined effects of these movement behaviors. The study aimed to identify movement patterns of physical activity, sitting time, and sleep and to examine the association of movement patterns with cognitive function. METHODS: This cross-sectional study included 1,240 participants aged ≥ 55 years participating in the Cooper Center Longitudinal Study who visited the Cooper Clinic, Dallas (2016-2019) for preventive health care. Four movement behaviors were self-reported, including leisure-time aerobic activity, muscle-strengthening activity, sitting time, sleep, and other characteristics. Cognitive function was assessed by the Montreal Cognitive Assessment (MoCA). Four categorical indicators were created for each movement behavior and used to identify latent classes. Information criterion, scaled relative entropy and model interpretability were used to determine the optimal number of classes. Participants were assigned to the predicted classes based on their highest posterior probabilities. Multinomial regressions examined the association between movement patterns and each covariate. Linear and logistic regression models examined the association of movement patterns and cognitive function. A sensitivity analysis accounted for misclassification errors. RESULTS: Participants were predominantly White (95%), male (71%), with an average age of 62 years. A 3-class model was selected, comprising class 1: active long sleepers, class 2: very active short sleepers, and class 3: moderately active short sleepers, representing 11%, 62%, and 27% of the sample. Compared to class 2, class 1 was more likely to be older and female, while class 3 was more likely to be female, have less education, be overweight and obese, and have chronic conditions. Compared to class 2, class 3 was associated with a lower MoCA total score, adjusting for sociodemographic factors. There were no differences in MoCA total score between class 2 and class 3 when further controlling for health behaviors and indicators. Sensitivity analysis accounting for misclassification suggested that class 3 had a significantly lower average MoCA total score than class 2. CONCLUSIONS: The current study identified three distinct movement classes that exhibited different sociodemographic, health characteristics and cognitive functions. Findings highlight that less active, more sedentary, and shorter sleep individuals had worse cognitive function.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.061
Threshold uncertainty score0.971

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.001
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.020
GPT teacher head0.294
Teacher spread0.274 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

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