World Cornea Congress IX (2025): Abstracts

Publications Rates and Characteristics of Registered Cornea Transplant Trials: An Analysis of Clinicaltrials.gov Leo Meller1, Ibrahim Abboud2, Steven Anderson2, and Natalie Afshari3 1Shiley Eye Institute, San Diego, CA; 2UC Riverside School of Medicine, Riverside, CA; and 3UC San Diego, San Diego, CA. Purpose: To characterize all registered corneal transplant (CT) trials. Methods: Information of all registered CT trials was extracted from Clinicaltrials.gov. Results: A total of 164 CT trials were identified with no time limits with the oldest from 1986, to which the majority were interventional (123, 75%), early phase or uncategorized (139, 84.8%), focused on adults only (142, 86.6%), non-industry sponsored (151, 92.1%). Principal investigators were predominately male (106, 64.6%), based internationally (114, 69.5%), and led by MD only (94, 57.3%). Interventional trials were more likely to be late phase (P = 0.002) and industry sponsored (P = 0.02) compared to observational trials. Among completed trials, 74 (63.2%) were published. International trials and trials focused on adults only were associated with publication (P = 0.003, P < 0.001, respectively). Conclusions: Less than two-thirds of completed CT trials were published in peer reviewed journals. Industry played a more significant role in interventional trials and international trials were associated with publication status. Increasing efforts is needed to improve rates of publication for timely dissemination of the latest advances in CT. “Needle” Keratoplasty Delivery of Endothelial Donor Grafts with a Novel Needle Delivery System Eric Abdullayev, and Arthur Kurz Lions World Vision Institute, Tampa, FL. Purpose: To introduce the first delivery device for the eye bank prepared/preloaded endothelial grafts to be delivered into the recipient's anterior chamber through the puncture. Methods: Donor corneas with healthy endothelium were used. 5 DMEK and 5 UT-DSAEK grafts were prepared loaded in the new delivery device with a needle insertion tip and stored for 5 days in Optisol-GS at 2 to 8 C. Then grafts were unloaded and endothelial viability was evaluated using specular microscopy and a new cell staining method. Images are digitally processed by the “ImageJ” image processing program. The percentage of the damaged cells was calculated. An artificial chamber with mounted donor corneas was used to recreate graft insertion through the puncture. Results: Mean preparation donor endothelial cells density was 2593 ± 89 cells/mm2 and post load - 2655 ± 95 cells/mm2. On the first day following preload, the mean endothelial cell loss was 5%, which remained stable at day 5. Endothelial specular microscopy and staining confirmed viable endothelium. All grafts were inserted through the needle puncture without difficulties. No fluid leaks were observed from the puncture wound. Conclusions: Eye bank-prepared pre-loaded DMEK and UT-DSAEK grafts in the new delivery device with a needle insertion tip survive storage for several days and can be successfully inserted for transplantation through puncture without prior blade incision. Ocular Features of Severe Vitamin Deficiency in Autistic Spectrum Disorder Children in the USA Anas Abuseif, Oliver Beale, and Ken Nischal UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA. Purpose: To describe 3 patients with autistic spectrum disorder (ASD) and peculiar restrictive diet who presented with severe vitamin A deficiency in the USA. Methods: Retrospective chart review. Results: Two (males) presented with blepharospasm, photosensitivity and night-blindness. Only at exam under anesthesia were bilateral corneal melts found in both. Both were treated with Amniotic Membrane Transplant with tarsorrhaphy; one underwent bilateral Gundersen flaps as a secondary procedure. One female presented with severe bilateral punctate epithelial erosions and blepharospasm. All patients had severe xerophthalmia, conjunctival ulceration, and Bitot's spots and received vitamin A intramuscularly along with aggressive lubricating eye drops. Behavioral therapy was needed together with continued oral Vitamin A to improve diet. All patients improved significantly. Conclusions: The possibility of severe vitamin A deficiency should be considered in ASD patients who present with photophobia and blepharospasm. Corneal Densitometry in Congenital Hereditary Endothelial Dystrophy: A Novel Attempt to Re Classify Corneal Clouding Muralidhar Ramappa1, Divya S. Achanta1, Anthony Aldave2, Deepak Edward3, and Sunita Chaurasia4 1L V Prasad Eye Institute, Hyderabad, Telangana, India; 2Stein Eye Institute, Los Angeles, CA; 3Department of Ophthalmology, Illinois Eye and Ear Infirmary, University of Illinois, Chicago, IL; and 4L V Prasad Eye Hospital, Hyderabad, Telangana, India. Purpose: To objectively grade corneal cloudiness in children with CHED and correlate it with clinical findings. Methods: This retrospective case-controlled study included 55 cloudy corneas from 32 CHED children, compared with 35 clear corneas from 18 age-matched healthy controls. Corneal densitometry (CD) was assessed using the WaveLight Oculyzer II, while central corneal thickness (CCT) was measured using anterior segment OCT. Corneal cloudiness was subjectively assessed via slit-lamp images and correlated with central 4 mm area densitometry. Objective corneal clouding grades were mild (28 eyes), moderate (16 eyes), and severe (5 eyes). Results: Combining clinical and imaging modalities, corneal clouding was graded as mild (52 eyes), moderate (25 eyes), and severe (9 eyes). The median age at the imaging time was 7.6 (5.3–10.1) years, with 58.3% being male. More advanced cases presented higher backscatter (P <0.0001). Mean central 4 mm area densitometry was significantly higher than age-matched healthy controls (P < 0.0001). Corneal grading comparisons showed a significant correlation between slit-lamp findings and densitometry measurements (P < 0.0001). CCT and LogMAR visual acuity were significantly correlated with area densitometry (P < 0.0001 and P = 0.004, respectively). Age at investigation and gender did not correlate with area densitometry (P = 0.32 and P = 0.19). Significant differences were observed for densitometry measurements across 4 annuli (P < 0.0001) and 3 corneal layers (P < 0.0001). Conclusions: A densitometry program is valuable for assessing corneal clouding in CHED patients. Densitometry measurements were significantly correlated with CCT and Log MAR visual acuity, indicating the program's utility in accurately evaluating corneal cloudiness in children with CHED. Validation of a Novel Technique to Measure Tarsal Conjunctival Thickness Using Anterior-Segment Optical Coherence Tomography Manokamna Agarwal1, Sara Williams2, Larissa Gouvea3, Asim Ali4, and Kamiar Mireskandari4 1University of Toronto, Toronto, ON; 2The Hospital for Sick Children, Toronto, ON; 3Storm Eye Institute, Charleston, SC; and 4Hospital for Sick Children, Toronto, ON. Purpose: This study aimed to validate a novel technique for measuring tarsal conjunctival thickness (TCT) using anterior segment optical coherence tomography (AS-OCT). By providing an objective measurement, to improve the grading for tarsal conjunctival as and Methods: This was a was on of to image the tarsal and were using of the with measurements in at Validation of measurements were for and using correlation and The study received and all Results: The study = with a mean of with differences to measurements showed = a mean of and differences to was = with a mean of and differences between and was = with a mean of and differences between and Conclusions: This study successfully a technique for measuring and This the to grading and clinical of tarsal conjunctival by providing an objective and of for clinical and in A India. Purpose: To differences in clinical of across age Methods: Retrospective study patients by gender and age for for Results: of had and had Both showed a male in and in 4 was in of gender in the grade 4 with was more in and grade 3 in A significant was in the clinical with being more in and in in was more in and in was the in across age Conclusions: is a male in across age gender in clinical are Endothelial in Corneal Grafts with and School of Medicine, and Eye Institute, Hospital, Purpose: for assessed in corneal transplantation by endothelial cell loss in corneal Methods: an in study using corneal grafts of = eyes), the eye was in of for and the eye in with of storage and images were by 2 were used for Results: The median age of was was no between median density of and controls (P = showed a significantly higher loss as compared to the controls (P = Conclusions: the study in cell loss with and are Analysis of Images can of a Novel Cornea Anthony Aldave2, and Eye 2Stein Eye Institute, Los Angeles, CA; School of Medicine, Chicago, IL; of Illinois Eye and Ear Infirmary, Chicago, IL; Eye Institute, School of at and and Purpose: To of anterior segment optical coherence tomography imaging of the to clinical of a Methods: anterior thickness with was used as and images were to the at A of images was and as the used to a to the in Results: The corneal of the using in the and in the showed no in the from The a loss at in in the Two in the showed anterior thickness of associated with of Conclusions: of corneal loss and A for the of Ocular Using Anterior-Segment and Eye Institute, of School of Medicine, and of FL. Purpose: To and validate a to between and and using anterior segment optical coherence tomography (AS-OCT). Methods: A was using 2 a was with images from and a Vision with the used images from by to a The of the was assessed on a of with and compared to the of Results: The an of with a of and of showed a of a higher of compared to the The area under the for the was significantly higher than of the = P < Conclusions: The in from and the was and in of and in a Hospital Purpose: To the of in patients and endothelial by corneal using a and describe of Methods: and and corneal from the were in a corneal and The was compared with the of for Results: of patients were Mean for the was higher than for the measured ± and ± The median in was ± and in total was ± significant (P < The was by with ± The to showed to the (P the for the was ± while for the was ± Conclusions: in corneas with should be and a significant for the while using the to a of of of with of in a and Divya Eye at University School of of School of Medicine, Eye Institute, Medicine, and Eye Institute, Purpose: To the of of with of corneal in patients. Methods: used from to for patients with at across was used to associated with of and Results: A total of of patients were patients patients with or based on were likely to no Conclusions: Using a found are associated with of of the role of in to early and for is of Corneal from to A Analysis and Divya Eye at University School of Medicine, Eye Institute, Medicine, Eye Institute, Hospital, and Eye Institute, Purpose: To describe for corneal and associated with Methods: from to were used to patients with corneal was used to associated with Results: A total of patients had corneal the study underwent a median of 4 days patients were likely to years, patients patients in and were likely to Conclusions: differences in the of corneal which The of Donor and with and Keratoplasty and Eye Hospital, Los Angeles, CA; and Eye Hospital, PA. Purpose: This study the of and age on graft and following Methods: This retrospective chart included from patients who underwent donor were for graft and using significant donor and using the to for Results: The had the of graft and graft time compared to only only donor and The age had the of graft and graft time compared to age age and the age The was not significant for graft or Conclusions: findings significant in on graft and age on graft and age be to patients on graft to on Eye 1University of Illinois at Chicago, IL; University of and Chicago, IL; of Medicine, University of for of Ophthalmology, and Eye Institute, University of for of Illinois Chicago, Chicago, IL; and of Ophthalmology, and Eye Institute, University of for Purpose: To the of 3 in and on eye Methods: evaluated by for 3 A and on with a using the Measure of for a of at a was assessed on and Results: All in to A and were of = and = were not were significantly more than A (P < and from a ± ± to were to no = only was to while and = Conclusions: were to and on were and of study the of as to of with in with and Ocular and and Purpose: is to describe a new for the of which is in the of the phase of the and as and present a the of the of oral or and it an and Methods: and of the with were A was prepared with of without and with a of of (5 and 2 and of (25 The of a on the of the the of the was by A needle was used. The first with was The was without the needle to the with the and in was for 3 Results: All the cases presented in study significantly the of the the of the phase of the not presented and for as of the from Conclusions: The of and with is an the and of More are to No More A Technique and and Purpose: to a new technique for of the of of patients in the by significantly and the post Methods: corneal and the and the conjunctival graft are to and the mm from in clear the in the of the The is the and at of the to the A is the of the is the clear and the to it was for the first time to a it can be in the a without on the the with into Results: All cases were and completed a of measured the of loss of and in and all patients only to the a was present in the first and the following of and were not as or No cases presented with visual acuity, or as corneal loss of the conjunctival or Conclusions: the of a new technique of conjunctival and which are the in the in the of Children with for and of and Purpose: This study evaluated children with to for in to or the of Methods: A study was on to who were with the total were treated with were and 5 were severe for were compared on anterior and mean and Results: significant differences were found across all The mean for was (P = was (P = and was (P = of treated and found a significant in P = Conclusions: with or of patients with and as as should be considered for of Corneal with in and Eye India. Purpose: with and in the corneal and the of the for optical in The of study is to the of in cases Methods: This is an Interventional study from to All 5 days of were to of and was to the of the of Results: and 8 with an age of 55 underwent to for were and 3 The of the was mm and was present in of the with a and 8 needed Conclusions: The study found was no of in the of No were to The of in to Severe Eye from the C. Divya 1University of of CA; with and and at School of and Vision of and Vision and of PA. Purpose: is considered the to and as new to are under is no clinical of and a of of and Using clinical from to of the of in patients with moderate to severe was Methods: a secondary of study with moderate to severe = clinical were used or in to in to of were as or not based on the and the was in were compared between with and without of with and and with was Results: The of in with moderate to severe from to age was associated with a higher of were used (P < age was not associated with was based on or (P for the of was significantly higher in for based on in the P < or was associated with a higher of compared with P < for based on and with and to be Conclusions: The of in on is and and of in trials on in University of Purpose: delivery to the eye is through the of eye is an only to of the in an eye the An for delivery is to higher and improved This is an on for and of to novel Methods: This an on novel delivery are under peer reviewed of and for eye and corneal and to are Results: of under investigation vitamin be reviewed with the and of on for delivery of and eye be as for eye day for be treated with be for of on the and loaded and of on the and the an for be more and for patients. Conclusions: for delivery improve and and no and are the an for be more and for patients. in Cornea Transplant and 1University of Illinois Chicago, Chicago, IL; of Ophthalmology, University of for 3Department of Ophthalmology, and Eye Institute, University of for and of Ophthalmology, and Eye Institute, University of for Purpose: To in transplantation by and using in Methods: were used to CT and into thickness thickness The was used to for and for across The were by and Results: The median and were and The median and were and was significant in by = P were for with Conclusions: the of significant for CT across and of on Images of Using and Eye Institute, Eye Institute, Eye Hospital and of Ophthalmology, India; San CA; University of San San CA; and Eye Institute, Purpose: This study the of a in the of images of for and of This to to and improve in patients with Methods: was to of into for to The study corneal from with was with a Results: an area under the of an of and an of was with an of while cases had an of and an of Conclusions: The in and the of from A of A and of and India; and of and India. Purpose: of in a who a presented with and in 2 with no of had and with eye drops. Methods: a corneal from 4 to measuring 2 mm mm with with a and mild and acuity was and was The included and and was on eye and eye Results: On 5 was only mild corneal was which for for which eye was to of the Conclusions: This the of as in the of corneal not to to the Keratoplasty Ali4, Divya Oliver and Eye Institute, University School of Medicine, University School of Medicine, Eye at School of Medicine, Eye Institute, School of Medicine, Eye Institute, Eye Institute, Medicine, and Eye Institute, Hospital, Purpose: To the rates of to the Methods: study who underwent Endothelial Keratoplasty Membrane Endothelial Keratoplasty Keratoplasty Keratoplasty at The Eye between and were by the of and of Rates of to the and associated for time the and was used to and Results: The to the days of was with the first was the and had the Conclusions: rates of to the can as a and to Corneal in with and Purpose: was to total corneal density by in in patients with and Methods: between to with and images were Results: the included patients ± were female and of patients for at The were and The had median total density of than the P = Conclusions: patients with had significant density compared to patients with Among Cornea Eric and of and and of Purpose: The 4 is the of endothelial corneal evaluated the of the as an study of the Endothelial Keratoplasty Methods: from were in with the were evaluated for a using and for The for was as Results: An of of identified in of Conclusions: findings of a on the of be The from an Ocular and San and Purpose: To the clinical spectrum of the Methods: Retrospective Results: A total of patients were patients were with a mean age of disorder was present in with being the included and were using and and The mean in was were eye and photophobia included included eye and and Conclusions: is an associated with by conjunctival and corneal to the for to Technique for in Keratoplasty and of India; India; and Prasad for India. Purpose: To describe the of as graft technique for donor in anterior Methods: A interventional study included 5 of 4 patients who underwent and had an donor The technique the preparation of a graft from the is to into the Results: the was along with the donor were no of graft or Conclusions: from the a and technique to cases of donor in with no of for Severe Eye to and of India; and Prasad for India. Purpose: To study the of transplantation for severe eye secondary to Steven Methods: was an interventional at Prasad for from to evaluating the of transplantation with of the to in cases of severe eye secondary to The clinical were compared to at Results: was an in median (P = (P = (P = corneal epithelial (P = corneal (P = corneal (P = of (P = corneal (P = and corneal (P = Conclusions: The transplantation is a viable for cases with severe eye secondary to Steven with clinical in corneal and conjunctival of the 3 on for University of Purpose: is it is associated with and severe is in to and Methods: A in late to study a with the of in based on with on Two trials of with is in Results: All showed a to thickness of for is to be completed by of and be Conclusions: in and An improved in the of visual loss at the of A to Corneal and and Purpose: a of corneal in to Methods: Results: A female with a of and 3 in the and 2 in the years, who a at and had corneal with no endothelial cells on specular (5 and an in as were underwent a and with a secondary DMEK was successfully in an was in Two with and the a of in and in with no of Conclusions: not for A Technique for in of Conjunctival and 1L V Prasad Eye Institute, India; Hospital, and Eye Hospital, India. Purpose: Conjunctival can or following conjunctival it to and the for be an epithelial or the of are to and is for to technique to the conjunctival of imaging and of the conjunctival following Methods: A male presented to the with in eye and underwent 2 of to eye with of while with All were and anterior segment conjunctival Results: The was in and for This was as conjunctival and Conclusions: the was to the of the the in the cases of is first in the of conjunctival was without of as and 1L V Prasad Eye Institute, India; and Eye Hospital, India. Purpose: is an of loss of and be associated with the of Methods: present with clinical which and Results: are a of in a which the for of and of investigation anterior segment optical coherence tomography in of and Conclusions: This the for of and of anterior segment optical coherence tomography in the of and with of and Divya 1L V Prasad Eye Institute, India; and Hospital, Purpose: as a are the for severe and of a can in a of cases of to the by for The not only for the of on associated with of a Methods: This was a retrospective study at eye in India. to the of Telangana, and All of patients who the from the of to were evaluated and all patients with were included in the This is the and study in India. Results: cases of were presented to the between and were between the of and and of were and visual were of 3 cases had cases had and had had visual the of had visual acuity between and had between and had between and cases had visual of which 2 had no of 2 had and the 2 had the of present and of Conclusions: This the of by and of for visual The can be successfully with to by of and by of of on of Corneal at a Eye in and 1L V Prasad Eye Institute, India; and Eye Hospital, India. Purpose: To study of on of corneal transplantation patients at a eye in of India. Methods: study at eye in of included patients who underwent thickness or at and who for Results: patients were using was significantly (P = than of the the patients were using was (P = to of the The of with clear grafts and significantly Conclusions: significant in of from to and at grafts from to the of from to in of at a Eye in to and 1L V Prasad Eye Institute, India; and Eye Hospital, India. Purpose: To study the in the of at a eye in to Methods: A retrospective study at a eye in of which included patients who underwent at of and of included associated or eye associated and visual acuity visual acuity corneal and at day and were Results: A significantly of from in to and significantly higher of or and or from in to were The of significantly to the of significantly to as compared to A significantly higher of with and with were observed the Conclusions: the was a from grade grade of the of significantly the of significantly the More of with and associated were observed the To Keratoplasty and 1L V Prasad Eye Institute, India; and Eye Hospital, India. Purpose: To study the of a in visual in Methods: A female underwent for for visual the was to the The was and the was the of The improved visual acuity from to 4 of observed significant corneal and visual acuity to Results: To corneal the between the and and of the while the 4 of showed corneal To the corneal is on the and corneal to 4 of while visual acuity the Conclusions: in significant in visual in post patients and is a for visual of Corneal at Eye

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