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Record W4411643312 · doi:10.1016/j.esmoop.2025.105187

58TiP ASCENT-GYN-01 (GOG-3104/ENGOT-en26): A randomized, phase III study of sacituzumab govitecan (SG) vs treatment of physician’s choice (TPC) in patients (pts) with endometrial cancer (EC) after platinum-based chemotherapy and immunotherapy

2025· article· en· W4411643312 on OpenAlexaff
N. Colombo, B.R. Corr, D. Cibula, David S.P. Tan, Noelle Cloven, Eva María Guerra Alia, K. Hasegawa, Tashanna Myers, Bruno You, V. Makker, Flora Zagouri, Lilian T. Gien, Michele Bartoletti, Adrianne Mallen, L. Woelber, Simonetta Mocci, K.M. Komatsubara, Ling Ma, Ramez N. Eskander

Bibliographic record

VenueESMO Open · 2025
Typearticle
Languageen
FieldMedicine
TopicEndometrial and Cervical Cancer Treatments
Canadian institutionsSunnybrook Health Science Centre
FundersGilead Sciences
KeywordsMedicineEndometrial cancerGynecologyCancerInternal medicine

Abstract

fetched live from OpenAlex

Pts with recurrent or metastatic EC progressing on or after platinum-based chemotherapy and programmed cell death (ligand)-1 (PD-[L]1) inhibitor therapy have limited treatment options. SG is a Trop-2–directed antibody-drug conjugate (ADC), approved in certain types of metastatic breast cancer. In the TROPiCS-03 study, SG demonstrated encouraging efficacy and manageable safety in pts with advanced/metastatic EC.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.174
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0020.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.016
GPT teacher head0.330
Teacher spread0.314 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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