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Record W4411652076 · doi:10.1021/acscentsci.5c00641

Elevated Toxic Element Emissions from Popular Disposable E-Cigarettes: Sources, Life Cycle, and Health Risks

2025· article· en· W4411652076 on OpenAlexaff
L. K. Saini, Tran B. Nguyen, Kent E. Pinkerton, Amy K. Madl, Austin M. Cole, Brett A. Poulin

Bibliographic record

VenueACS Central Science · 2025
Typearticle
Languageen
FieldEnvironmental Science
TopicHeavy Metal Exposure and Toxicity
Canadian institutionsIONICS Mass Spectrometry (Canada)
FundersNational Institute of Environmental Health SciencesDivision of Agriculture and Natural Resources, University of CaliforniaTobacco-Related Disease Research Program
KeywordsEnvironmental scienceBusinessEnvironmental healthWaste managementChemistryEngineeringMedicine

Abstract

fetched live from OpenAlex

The rapidly evolving market of disposable e-cigarettes poses unknown health risks to adolescents and young adults. We report excessive emissions of toxic metallic elements in aerosols from flavored and "clear" versions of three popular products (Esco Bar, Flum Pebble, and ELF Bar), orders of magnitude higher in concentration than traditional cigarettes and other e-cigarettes. Heating coil elements (chromium (Cr), nickel (Ni)) likely leached into e-liquids and aerosols from coil degradation during use, increasing up to 1000-fold in concentration over the device life. In Esco Bar devices, high concentrations of lead (Pb, ≤175 ppm), Ni (≤38 ppm), copper (Cu, ≤546 ppm), and zinc (Zn, ≤462 ppm) were observed in both e-liquids and aerosols. We identified the illicit use of leaded bronze in nonheating device components in contact with e-liquid as the source of Pb. Elevated antimony (Sb) in Flum Pebble and Esco Bar samples had unknown origins. Analyses showed Cr was present as nontoxic Cr-(III), while Sb was a mixture of nontoxic Sb-(V) and carcinogenic Sb-(III). Risk assessments revealed cancer risks from Ni and Sb-(III) and noncancer toxicity risks from Pb and Ni exceeded safety thresholds. These findings highlight critical gaps in e-cigarette regulation, characterization, and enforcement, with implications for public health.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.003

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.022
GPT teacher head0.290
Teacher spread0.267 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations24
Published2025
Admission routes1
Has abstractyes

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Same venueACS Central ScienceSame topicHeavy Metal Exposure and ToxicityFrench-language works237,207