Bibliographic record
Abstract
Diabetes is a multi-factorial disease that requires a multiple therapeutic approach to adequately control the multiple metabolic abnormalities of the disease.The present study evaluated the in vitro antioxidant and antidiabetic potentials of the combination (2:1) of the aqueous leaf extracts of Leptadenia hastata (LH) and Momordica balsamina (MB).The in vitro inhibitory effects of the combination on antioxidant indices and key enzymes of carbohydrate hydrolysis and polyol pathway were evaluated and the test extract's potencies were expressed in terms of IC50 values.The combination exhibited potent in vitro ferric reducing power (IC50 29.28±0.29 µg/ml), scavenging activity (IC50 90.05±25.89µg/ml), alpha amylase (IC50 15.86±1.03µg/ml), alpha glucosidase (IC50 330.93±26.47µg/ml) and aldose reductase (IC50 37.30±2.27µg/ml) inhibitory potentials when compared to the standard drugs.Findings of the present study demonstrated the anti-diabetic potential of the combination as evidenced by their observed in vitro biochemical activities.This provides a background for further studying the antidiabetic and antioxidant potentials of the polyherbal combination in animal models of diabetes.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.003 | 0.001 |
| Insufficient payload (model declined to judge) | 0.945 | 0.946 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; the direct Gemma label and the distilled Codex classifier agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".