Correction of the neurotransmitter pool as a new approach in the treatment of patients with multifocal atherosclerosis
Bibliographic record
Abstract
Multifocal atherosclerosis (MAS) is associated with the development of ischemia in many organs and a significant deterioration in the prognosis for patients. An important role in this disease is played by the imbalance of neurotransmitters and increased content of matrix metalloproteinases (MMP) caused by ischemia. The aim of the study was to develop approaches to drug optimization of blood levels of dopamine, histamine and MMP in patients with multifocal atherosclerosis. The study included: 66 men with MAS aged 67.2 ± 2.9 years, who were divided into two groups: group 1 – patients with ischemic stroke, group 2 – patients with myocardial infarction, common to patients in both groups were atherosclerotic encephalopathy, ischemic heart disease and intermittent claudication syndrome; the control group consisted of 18 practically healthy men aged 63.4 ± 5.1 years. In addition to the basic treatment, patients received cilostazol (50 mg twice a day), GABA – aminalon (250 mg twice a day), atenolol (25 mg once a day) and catechins – Green T-Max (1 capsule per day) for 16 weeks. The examination included: determination of volumetric blood flow (FV) in the coronary, cerebral and femoral vascular territories, walking distance, daily ECG monitoring, estimation of dopamine and histamine levels in serum and MMP-2,-9 level in blood plasma by ELISA. Cognitive function was determined using the Montreal scale. Significantly lower FV in the studied vascular areas and extremely high histamine and dopamine levels were found in both MAS groups compared with the control group. The levels of MMP-2 and MMP-9 in both groups notably exceeded the indices in control group. After additional treatment with the studied medications, the drop in excessively high levels of histamine, dopamine, MMP-2 and MMP-9l was observed, the clinical condition, FV, cognitive functions and walking distance in patients of both MAS groups were improved. Thus, the use of the combination of cilostazol, aminalon, atenolol and catechins, in addition to standard therapy, allowed us to optimize the levels of neurotransmitters dopamine and histamine, which may reduce the risk of recurrent cardiovascular events in patients with MAS. Keywords: dopamine, histamine, metalloproteinases-2, metalloproteinases-9, multifocal atherosclerosis
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".