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Record W4411671071 · doi:10.1016/j.jamda.2025.105722

Usage and Costs of Regular Acetaminophen (Paracetamol) in Canadian Long-Term Care Facilities

2025· article· en· W4411671071 on OpenAlexafffundabout
Roni Kraut, Xueyi Chen, Scott Garrison, Erik Youngson, Cheryl A Sadowski, Christian Ono, Andrea Gruneir

Bibliographic record

VenueJournal of the American Medical Directors Association · 2025
Typearticle
Languageen
FieldPharmacology, Toxicology and Pharmaceutics
TopicDrug-Induced Hepatotoxicity and Protection
Canadian institutionsWestern UniversityAlberta Health ServicesAlberta HealthUniversity of Alberta
FundersPfizer CanadaUniversity of AlbertaPfizer
KeywordsMedicineAcetaminophenTerm (time)Long-term careMedical emergencyEmergency medicineIntensive care medicineAnesthesiaNursing

Abstract

fetched live from OpenAlex

Objectives Evidence suggests that the use of regular acetaminophen (paracetamol) in long-term care (LTC) is a low-value intervention, that it does not improve pain or quality of life, and that it has the potential for adverse effects. Our objective was to assess the usage of regular acetaminophen in Canadian LTC facilities as well as the costs associated with its use. Design Cross-sectional study. Setting and Participants Canadian LTC facilities serviced by a national LTC pharmacy provider in 2022. Methods Descriptive statistics were used to characterize prevalence, dosing, dispensation frequency, type, and costs of regular acetaminophen dispensations (cost of tablets, carbon emissions, and nursing dispensation time). Results The data set included 49,419 residents (median age: 86, women: 65%) from British Columbia (5.5%), Alberta (7.1%), Manitoba (23.0%), and Ontario (64.4%). The mean prevalence of regular acetaminophen dispensations was 45.7%. Among residents dispensed regular acetaminophen, 85% of residents were dispensed >1000 mg of acetaminophen/day, the mean defined daily dose per 1000 residents per 1 day was 317 [standard deviation (SD) 56], 59.3% were dispensed acetaminophen ≥3 times per day, and dispensations were approximately evenly split between 325- and 500-mg tablets. The 27.8 million tablets of acetaminophen dispensed in 2022 cost $870,000; had a carbon footprint of 54.8 tonnes of carbon dioxide equivalents (CO 2 e); and required 191,000 nursing hours, the equivalent of 92 nurses working full-time for 1 year. Conclusion and Implications Regular acetaminophen use is highly prevalent in LTC and has substantial costs. It would be advantageous to re-examine acetaminophen use in LTC facilities.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.080
Threshold uncertainty score0.964

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.026
GPT teacher head0.373
Teacher spread0.347 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes3
Has abstractyes

Explore more

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