Metabolome analysis of Eriocheir sinensis serum under air exposure at low temperature
Bibliographic record
Abstract
Air exposure is a common stressor that disrupts the physiological activities of aquatic crustaceans. Low temperature can effectively alleviate the stress caused by air exposure. The study investigates the metabolic response of Eriocheir sinensis to air exposure at low temperature using serum metabolomics. Exposure to the stress induces increase in tricarboxylic acid (TCA) cycle intermediates and phospholipids. This metabolic shift is crucial for enhancing energy production and facilitating dynamic remodeling of the cell membrane. And the enrichment of the hypoxia-inducible factor-1 (HIF-1) signaling pathway and the ATP-binding cassette (ABC) transporter pathway suggests the activation of signal transduction processes. Moreover, the enhanced activities of autophagy, efferocytosis, and the Forkhead Box (FoxO) signaling pathway reflect the reinforcement of the immune defense mechanism. These results clearly indicate that E. sinensis can correspond to the stress through multi-dimensional regulation. This study can provide theoretical basis for in-depth understanding of the environmental adaptation strategies of E. sinensis and offer valuable references for the scientific management during its cultivation and transportation.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".