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Modeling Health and Economic Outcomes of Providing Stable Housing to Homeless Adults With OUD

2025· article· en· W4411715565 on OpenAlexaff
Isabelle J. Rao, Margaret L. Brandeau

Bibliographic record

VenueJAMA Network Open · 2025
Typearticle
Languageen
FieldHealth Professions
TopicHomelessness and Social Issues
Canadian institutionsUniversity of Toronto
FundersNational Institute on Drug Abuse
KeywordsMedicineOpioid use disorderDemographyStatus quoQuality-adjusted life yearOpioid overdoseCost effectivenessGerontologyOpioidInternal medicineEconomics

Abstract

fetched live from OpenAlex

Importance: The number of people experiencing homelessness (PEH) in the US has increased substantially in recent years. The leading cause of death among PEH is drug overdose, with opioids accounting for the majority of such deaths. Objective: To assess the costs and health outcomes of providing stable housing to PEH who have opioid use disorder (OUD). Design, Setting, and Participants: This economic evaluation conducted a model-based cost-effectiveness analysis of PEH with OUD in the US. Exposure: Provision of stable housing, with no requirement to enter OUD treatment. Main Outcomes and Measures: Primary outcomes were overdoses and deaths over 5 years, lifetime per-person discounted quality-adjusted life-years (QALYs) and costs, and incremental cost-effectiveness ratios (ICERs) compared with the status quo (no housing provision). Results: In a model of 1000 PEH (700 male; mean [SD] age, 46.4 [14.0]; 300 female; mean [SD] age, 46.5 [14.3]), under the status quo, 191 (95% CI, 152-237) deaths occurred over 5 years (58 [95% CI, 44-78] from overdose and 133 [95% CI, 101-167] from other causes). With the housing intervention, 140 (95% CI, 114-185) deaths occurred (53 [95% CI, 39-76] from overdose and 87 [95% CI, 73-110] from other causes). The housing intervention was associated with a gain of 3.59 (95% CI, 3.13-3.98) lifetime QALYs per person at an incremental cost of $26 800 (95% CI, $21 200-$32 300) per QALY gained compared with the status quo. Over extensive sensitivity analyses, the ICER remained less than $90 000 per QALY gained. Conclusions and Relevance: This economic evaluation found that investing in stable housing for this marginalized population, even with no requirement to enter OUD treatment, was associated with cost-effectiveness, fewer deaths, and improved health outcomes. Efforts are urgently needed to improve the health of PEH with OUD; it is essential to understand the outcomes and cost-effectiveness of housing provision for this marginalized population because housing status is a key social determinant of health.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.754
Threshold uncertainty score0.985

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.047
GPT teacher head0.404
Teacher spread0.357 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2025
Admission routes1
Has abstractyes

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