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Record W4411726640 · doi:10.1371/journal.pone.0326428

Needs assessment and preparedness of the primary health care network for scaling-up preventive tuberculosis treatment in 5 Brazilian capitals

2025· article· en· W4411726640 on OpenAlexaff
Dinah Carvalho Cordeiro, Pedro Kuabara, Bruna Chiarini Amaral, Lucas Maia Portugal, Daniel Souza Sacramento, Larissa Bertacchini de Oliveira, Priscilla Wolter Paolino, Vanessa Cordeiro Vilanova, Cristina Bettin Waechter, Anete Trajman

Bibliographic record

VenuePLoS ONE · 2025
Typearticle
Languageen
FieldMedicine
TopicTuberculosis Research and Epidemiology
Canadian institutionsMcGill UniversityMcGill University Health Centre
Fundersnot available
KeywordsTuberculosisMedicineTuberculinPreparednessRadiological weaponLatent tuberculosisInterferon gamma release assayFamily medicineMedical emergencyMycobacterium tuberculosisSurgeryPathology

Abstract

fetched live from OpenAlex

This study aims to conduct a needs and preparedness assessment of public primary care units to scale up tuberculosis infection diagnosis and tuberculosis preventive treatment in 5 Brazilian capitals. This observational operational study was carried out across five Brazilian high tuberculosis-burden cities. Clinics with at least one monthly new tuberculosis case were included. Data on Purified Protein Derivative (PPD) storage, tuberculin skin testing (TST) and interferon-gamma release assay (IGRA) availability, personnel qualified for performing TST, radiological facilities and tuberculosis preventive treatment drug availability, were gathered between August 2023 and January 2024. Out of 285 clinics included, 78% (CI95%: 73%-82%) did not offer TST on-site, with only 28% (CI95%: 22%3%) having staff qualified to perform TST, and 35% (CI95%: 29%-40%) lacking dedicated refrigerators for PPD storage. Most (97%, CI95%: 94%-99%) clinics did not collect IGRA testing, with an average distance of 6.7 km (CI95%: 5%-7%) to IGRA labs and a turnaround time of 11.7 days (CI95%: 9%13%) for results. Most (87%, CI95%: 83%-91%) do not offer on-site radiological testing. The primary care network was unprepared to scaling up tuberculosis infection testing. Key issues include unavailability of TST mainly because of insufficient qualified personnel. Without accelerated qualification of staff for TST, scaling up tuberculosis preventive treatment will be impossible.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.011
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.035
Threshold uncertainty score0.070

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.011
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0010.002
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.033
GPT teacher head0.353
Teacher spread0.320 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

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