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Record W4411867631 · doi:10.1371/journal.pgph.0004644

Costs of testing sick children in primary care with pulse oximetry: Evidence from four countries, both with and without electronic clinical decision support

2025· article· en· W4411867631 on OpenAlexaff
Susan Horton, Ulrich Adombi, Fenella Beynon, Mira Emmanuel-Fabula, Tara Herrick, Sandeep Kumar, Suzan Makawia, M. Mugo, Michael Nnachebe Onah, Michael Ruffo, Shally Awasthi, Maymouna Ba, Leah F. Bohle, Silvia Cicconi, Hélène Langet, Papa Moctar Faye, Honorati Masanja, Andolo Miheso, Deusdedit Mjungu, James Machoki M’Imunya, Ousmane Ndiaye, Kovid Sharma, Valérie D’Acremont, Kaspar Wyss

Bibliographic record

VenuePLOS Global Public Health · 2025
Typearticle
Languageen
FieldMedicine
TopicEmergency and Acute Care Studies
Canadian institutionsUniversity of Waterloo
FundersUnitaid
KeywordsMedicineTanzaniaReferralIntegrated Management of Childhood IllnessDispensaryEmergency medicineRandomized controlled trialFamily medicinePediatricsMedical emergencyEnvironmental healthPrimary health carePopulationSurgery

Abstract

fetched live from OpenAlex

Introducing pulse oximeters (PO) at primary care facilities can help health workers identify severely ill children who need referral to hospital thereby allowing for improved child clinical outcomes. Adding clinical decision support algorithms (CDSA) can improve adherence to Integrated Management of Childhood Illness guidelines. The current study analyses the costs of introducing PO either with or without an electronic CDSA using an RCT in India and Tanzania and in a pre-post design with an electronic CDSA in Kenya and Senegal. The impact of the intervention is discussed for the RCT (trial registration NCT04910750) and for the pre-post study (trial registration NCT05065320), following SPIRIT guidelines. Economic data were collected in all four countries using questionnaires administered at primary health facilities and referral hospitals and supplemented by information from administrative sources, following CHEERS guidelines. Trained research assistants at the facilities collected data on children enrolled and health outcomes. Net costs per 100 children managed using PO ranged from $16.62 (Kenya, health center) to $70.51 (Tanzania, dispensary), in both cases using CDSA. Senegal was an outlier at $385.45, using PO and CDSA in the smaller postes de santé. Major causes explaining variation included training modality, numbers of sick children attending the facility, and the effect of PO and CDSA on use of antibiotics, diagnostics, and hospitalizations. Standard care (without PO) was associated with fewer severe complications (primarily untimely hospitalizations), at lower cost, in the two countries where effectiveness data are available, India and Tanzania. Scaling up PO use at primary care level nationally could have an important budgetary impact. Findings suggest ways that costs could potentially be reduced. However, hospitalization costs borne by households may affect both household and provider behavior and limit the potential clinical benefits of pulse oximetry.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.032
Threshold uncertainty score0.909

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.040
GPT teacher head0.350
Teacher spread0.310 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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