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Daily use of countermeasures to prevent headward fluid shifts throughout 30 days of strict head-down tilt bed rest

2025· article· en· W4411875791 on OpenAlexaff
Steven S. Laurie, Jason R. Lytle, Sarah K. Pickering, Matthew J. Poczatek, Stuart M. C. Lee, Laura P. Pardon, Annelise Miller, David S. Martin, Edwin Mulder, Stefan Moestl, Dominik Pesta, Timo Frett, Claudia Stern, Jens Tank, Jan‐Niklas Hönemann, SriniVas R. Sadda, Rustum Karanjia, Karina Marshall‐Goebel, Millennia Young, Christine Cole, Alex S. Huang, Brandon R. Macias

Bibliographic record

VenueJournal of Applied Physiology · 2025
Typearticle
Languageen
FieldMedicine
TopicSpaceflight effects on biology
Canadian institutionsUniversity of Ottawa
FundersResearch to Prevent BlindnessNational Aeronautics and Space Administration
KeywordsCuffMedicineSpaceflightBed restHead-Down TiltWeightlessnessAnesthesiaInternal medicineSurgeryCardiology

Abstract

fetched live from OpenAlex

We demonstrate that daily use of lower body negative pressure or venoconstrictive thigh cuffs following aerobic exercise is well tolerated throughout 30 days of exposure to the spaceflight analog strict head-down tilt bed rest. Both countermeasures reduced SV and internal jugular vein cross-sectional area, indicators of the venous fluid shift, but to a lesser degree than the upright posture.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.422
Threshold uncertainty score0.844

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0020.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.025
GPT teacher head0.322
Teacher spread0.297 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2025
Admission routes1
Has abstractyes

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