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Record W4411878731 · doi:10.2337/dc25-0765

Physical Activity Is Associated With Improved Glycemic Outcomes in Newly Diagnosed Youth With Type 1 Diabetes: 4T Exercise Program

2025· article· en· W4411878731 on OpenAlexaff
Dessi P. Zaharieva, Victor Ritter, Franziska K. Bishop, Manisha Desai, Ananta Addala, Priya Prahalad, Michael C. Riddell, David M. Maahs, Korey K. Hood, David Scheinker, Ramesh Johari, Diana Naranjo, Molly L. Tanenbaum, Emily B. Fox, Carlos Guestrin, Mark A. Clements, Ana L. Cortes, ILENIA BALISTRERI, ALONDRA LOYOLA, Rachel Tam, Eliana Frank, JEANNINE LEVERENZ, Anji Martinez-Singh, Barry Conrad, Annette Chmielewski, Shannon Lin, Kim Clash, Julie Senaldi, Lauren Horton, Mindy Lee, Gloria Kim, Paul Dupenloup, Pierre-Amaury Laforcade, Isha Thapa, Victoria Y. Ding, Blake Shaw, Bryan Bunning, Johannes O. Ferstad, Jamie Kurtzig, Natalie M. Pageler, Simrat Ghuman, Brendan Watkins, Glenn Loving

Bibliographic record

VenueDiabetes Care · 2025
Typearticle
Languageen
FieldMedicine
TopicDiabetes Management and Research
Canadian institutionsLMC Diabetes & Endocrinology (Canada)York University
FundersNational Center for Advancing Translational SciencesNational Institute of Diabetes and Digestive and Kidney DiseasesLeona M. and Harry B. Helmsley Charitable Trust
KeywordsMedicineInterquartile rangePedometerPhysical activityDiabetes mellitusType 2 diabetesGlycemicType 1 diabetesInternal medicinePhysical therapyEndocrinology

Abstract

fetched live from OpenAlex

OBJECTIVE: The Teamwork, Targets, Technology, and Tight Range (4T) Exercise Program evaluated physical activity patterns across the first year of type 1 diabetes diagnosis and whether physical activity was associated with changes in glucose outcomes in the 24 h following physical activity. RESEARCH DESIGN AND METHODS: The 4T Exercise Program started newly diagnosed youth with type 1 diabetes on a continuous glucose monitoring (CGM) system and physical activity tracker around 1 month postdiagnosis. A subset of youth opted to participate in up to four quarterly structured exercise education sessions to increase their knowledge around safe physical activity. RESULTS: Ninety-eight youth with type 1 diabetes (median [interquartile range (IQR)] age of 13 [12-15] years, 45% female, 44% non-Hispanic White) completed the study. Compared with sedentary days, days with ≥10 min of vigorous-intensity physical activity were associated with an increase in time in range (TIR) of 2.3% (1.4-3.2%; P < 0.001), a decrease in time above range (TAR) of 3.1% (2.2-4.0%; P < 0.001), and an increase in time below range (TBR) of 0.8% (0.6-0.9%; P < 0.001) in the 24 h following physical activity. From 1-3 months to 10-12 months postdiagnosis, the median (IQR) step count increased by 1,134 (445-1,519) steps per day (P < 0.001), while daily moderate-to-vigorous physical activity increased by 11 (2-23) min per day (P < 0.001). CONCLUSIONS: In the 24 h following physical activity as compared with sedentary days, TIR improved, TAR was lower, and TBR remained within clinical target recommendations. For youth with new-onset type 1 diabetes, each structured exercise education session was associated with a further 0.79% increase in TIR.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Non-randomized trial · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.010

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.288
Teacher spread0.275 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNon-randomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations5
Published2025
Admission routes1
Has abstractyes

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