The Association Between Body Composition and Treatment and Disease Outcomes in Patients with Juvenile Idiopathic Arthritis: Results from the CAPRI Registry
Bibliographic record
Abstract
Objectives Recent evidence has linked abnormal body weight, underweight or obesity, with poor disease outcomes in adults with inflammatory arthritis. Yet, little is known about potential similar associations in children with JIA. Therefore, we investigated the association between BMI categories and time to start treatments and attain disease outcomes in children with JIA. Methods Data were captured prospectively through the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) JIA Registry. This national research registry follows newly diagnosed patients with JIA and collects data at each clinic visit. Based on age, sex, height, and weight at enrollment, BMI was categorized for each patient as underweight (<5 th percentile), healthy (5th to <85th percentile), overweight (85th to <95th percentile), or obese (≥95th percentile) according to the WHO growth charts. For each BMI category, Kaplan-Meier curves examined time to clinical Juvenile Arthritis Disease Activity Score 10 (cJADAS10) ≤1, pain score (parent- and patient-reported) <1, quality of life (patient-reported) >9, parent global assessment <1, physician global assessment <1, and active joint count <1. For these disease outcomes, shorter times are considered optimal. Time to start treatments included conventional DMARD, biologic DMARD, joint injections, and systemic corticosteroids. Log-rank tests compared outcomes across BMI categories; healthy served as the reference category. Results We included 759 patients enrolled in the Registry between February 2017 and May 2023 (61% female; mean±SD age 9.5±4.7 years). The obese group took significantly longer to attain cJADAS10 ≤1 (χ2(1)=5.53, p=0.019, median difference in time to reach outcomes compared to reference category [MD]=36 weeks), parent pain score <1 (χ2(1)=5.90, p=0.015, MD=46 weeks), and parent global assessment <1 (χ2(1)=5.49, p=0.019, MD=11 weeks). Time to first DMARD was significantly shorter in obese patients (χ2(1) =4.34, p=0.037, MD=15 weeks), and time to first biologic was significantly shorter in underweight patients (χ2(1)=4.65, p=0.031, MD=185 weeks) (Figure 1). No other examined treatments or outcomes were significantly different between BMI categories. Figure 1: Kaplan Meier Curves Conclusion Children with JIA in the obese group took longer to attain disease control based on both clinical and parent-reported outcomes compared to those with healthy BMI, despite earlier treatment escalation to DMARDs. Additionally, those who were underweight also required earlier treatment escalation to biologics. Further analyses will explore weight percentile groups, covariates including ethnicity and JIA subtype, and changes in body composition overtime. Altogether, these findings may help inform clinicians on anticipated treatment responses and disease outcomes when educating and counseling families about body composition.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.009 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.004 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".