Insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 in central precocious puberty: a systematic review and meta-analysis
Bibliographic record
Abstract
To identify distinct patterns of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein 3 (IGFBP-3) in girls with central precocious puberty (CPP), and to compare IGF-1 and IGFBP-3 levels in patients with CPP and precocious thelarche (PT). A literature search of PubMed, Embase, and Scopus databases was done to identify observational studies. Newcastle-Ottawa Scale (NOS) was used to assess the quality of the studies. Pooled weighted mean difference (WMD) and 95% confidence intervals (CI) were reported. Fourteen studies were included. As opposed to age-matched or similar-aged pre-pubertal girls, patients with CPP had significantly higher levels of IGF-1 and IGFBP-3. CPP was associated with higher levels of IGF-1 approaching statistical significance but similar levels of IGFBP-3 compared to PT. Distinct hormonal patterns, such as elevated IGF-1 and IGFBP-3, were identified in patients with CPP, suggesting a potential diagnostic value of IGF-1 and IGFBP-3 levels.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.004 |
| Meta-epidemiology (narrow) | 0.004 | 0.003 |
| Meta-epidemiology (broad) | 0.028 | 0.006 |
| Bibliometrics | 0.005 | 0.007 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.004 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".