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Record W4411957713 · doi:10.1016/j.mex.2025.103480

A novel method for evaluating the efficacy of pharmaceuticals against the in vivo stage of Ichthyophthirius multifiliis in fish

2025· article· en· W4411957713 on OpenAlexaff
Guangran Hu, Qingwen Zeng, Ke Huang, Hong Zou, Wenxiang Li, Shangong Wu, Guitang Wang, Ming Li

Bibliographic record

VenueMethodsX · 2025
Typearticle
Languageen
FieldImmunology and Microbiology
TopicAquaculture disease management and microbiota
Canadian institutionsMinistry of Agriculture
FundersNational Key Research and Development Program of ChinaEarmarked Fund for China Agriculture Research SystemChinese Academy of SciencesNational Natural Science Foundation of China
KeywordsIchthyophthirius multifiliisFish <Actinopterygii>In vivoStage (stratigraphy)BiologyFisheryBiotechnology

Abstract

fetched live from OpenAlex

This study presents a description of a novel apparatus for evaluating the efficacy of pharmaceuticals against the in vivo stage of the fish parasite Ichthyophthirius multifiliis . The apparatus comprises a transparent acrylic rectangular cuboid, a metal wire mesh, and a gridded black acrylic bottom plate. Fallen trophonts are caught on the bottom plate and are separated from the fish by the mesh. The efficacy of a pharmaceutical can be assessed by adding it to the aquarium and subsequently counting the number of live tomonts and differntiating rate on the bottom plate. This device facilitates observation and enhances the precision and accuracy of pharmaceutical evaluation experiments.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.005
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.157
Threshold uncertainty score0.398

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0050.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.081
GPT teacher head0.446
Teacher spread0.365 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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