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Record W4411959630 · doi:10.1016/j.devcel.2025.06.016

Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma through an innate immune process

2025· article· en· W4411959630 on OpenAlexafffund
Carolina Nör, Kaitlin Kharas, Alex Rasnitsyn, Maria Vladoiu, Nam Woo Cho, Jacob S. Young, Felipe Nör, Ncedile Mankahla, Joonas Haapasalo, Kristiina Nordfors, Sara Rapic, Patryk Skowron, Raúl A. Suárez, Alexander T. Bahcheli, Oliver Ocsenas, Xin Chen, Shahrzad Bahrampour, Ali Momin, Lakshmikirupa Sundaresan, Winnie Ong, Liam D. Hendrikse, Namal Abeysundara, Kyle Juraschka, Michelle Ly, Jonelle G. Pallota, Tajana Douglas, Ning Huang, Hao Wang, Lei Qin, Jessica Liu, Lily Shen, Betty Luu, Alex Manno, Sachin Kumar, Laura Donovan, Vernon Fong, Cory M. Richman, Craig Daniels, Livia Garzia, Jeremy N. Rich, Cynthia Hawkins, Xiaochong Wu, Ralph S. DaCosta, Jüri Reimand, Xi Huang, Vijay Ramaswamy, David R. Raleigh, Michael D. Taylor

Bibliographic record

VenueDevelopmental Cell · 2025
Typearticle
Languageen
FieldMedicine
TopicGlioma Diagnosis and Treatment
Canadian institutionsMcGill University Health CentreOntario Institute for Cancer ResearchUniversity Health NetworkSickKids FoundationPrincess Margaret Cancer CentreHospital for Sick Children
FundersNational Cancer InstituteGarron Family Cancer CentreHealth CanadaNational Institutes of HealthOntario Institute for Cancer ResearchCanada Research ChairsConselho Nacional de Desenvolvimento Científico e TecnológicoBrain Tumour CharityFondation De Famille Alvin SegalHospital for Sick ChildrenGenome British ColumbiaCanadian Cancer SocietySwifty FoundationCancer Research UKNational Institute of Neurological Disorders and StrokeStand Up To Cancer CanadaRally FoundationOntario Research FoundationCanadian Cancer Society Research InstituteMatthew Larson Foundation for Pediatric Brain TumorsFondation Brain CanadaWorldwide Cancer ResearchV Foundation for Cancer ResearchBrain Tumour Foundation of CanadaGenome CanadaCanadian Institutes of Health ResearchTerry Fox Research InstituteCancer Prevention and Research Institute of TexasUniversity of TorontoStand Up To CancerEntertainment Industry FoundationC.R. Younger FoundationPediatric Brain Tumor FoundationAmerican Association for Cancer Research
KeywordsBiologyMedulloblastomaInnate immune systemProcess (computing)Immune systemCancer researchNeuroscienceImmunologyComputer science

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.188
Threshold uncertainty score0.469

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.296
Teacher spread0.288 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2025
Admission routes2
Has abstractno

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