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Record W4411990337 · doi:10.1101/2025.07.03.662942

Prior Information Shapes Perceptual Evidence Accumulation Dynamics Differentially in Psychosis

2025· preprint· en· W4411990337 on OpenAlexaff
Léon Franzen, S. Eickhoff, Christina Andreou, Ioannis Delis, Julia Erb, Jens Kreitewolf, Rebekka Lencer, Claudia Lange, Lea‐Maria Schmitt, Niels A Kloosterman, Sarah Tune, Stefan Borgwardt, Jonas Obleser

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2025
Typepreprint
Languageen
FieldNeuroscience
TopicFunctional Brain Connectivity Studies
Canadian institutionsMcGill University
Fundersnot available
KeywordsPsychosisDynamics (music)PerceptionPsychologyCognitive psychologyComputer scienceCommunicationNeurosciencePsychiatry

Abstract

fetched live from OpenAlex

Abstract Humans rely on prior information to navigate sensory uncertainty: Such priors could shape the decision process before sensory evidence is gathered (origin model), or could amplify sensory evidence dynamically (gain model). Dysfunctionalities in the utilisation of priors may underlie hallucinatory percepts and delusional ideation in psychosis, yet their impact on decision-making across sensory modalities has remained unclear. Using a perceptual target-detection task across auditory and visual domains in laboratory and online samples, we applied hierarchical drift diffusion modelling to examine how prior probabilities shape evidence accumulation in clinical and non-clinical populations. We show that in healthy individuals, prior information enhances sensory gain and decision flexibility, as represented by drift criterion and rate, consistent with the gain model. In contrast, individuals with psychosis exhibit diminished sensory gain, relying instead on pre-evidence biases, consistent with the origin model. Notably, greater positive symptom severity predicted a reduction in traditional criterion decision bias. These results suggest that sensory gain deficits may serve as a computational marker for psychosis progression, linking dysfunctional prior use to perceptual aberrancies. By demonstrating how prior information modulates evidence accumulation across sensory modalities, our study advances the understanding of psychotic perception and decision-making, offering insights for computational psychiatry and fine-tuned clinical diagnostics.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.010
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.008

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.010
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.048
GPT teacher head0.282
Teacher spread0.235 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

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Same venuebioRxiv (Cold Spring Harbor Laboratory)→Same topicFunctional Brain Connectivity Studies→French-language works237,207→