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Record W4412052969 · doi:10.1101/2025.07.04.25330845

Evaluating the accuracy and consistency of ChatGPT for the management of type 2 diabetes: A cross-sectional study

2025· preprint· en· W4412052969 on OpenAlexaff
Danielle Cutler, Tamara Van Bakel, Patricia Olar, Michael Fralick

Bibliographic record

VenuemedRxiv · 2025
Typepreprint
Languageen
FieldMedicine
TopicArtificial Intelligence in Healthcare and Education
Canadian institutionsLunenfeld-Tanenbaum Research InstituteSinai Health System
Fundersnot available
KeywordsConsistency (knowledge bases)Type 2 diabetesCross-sectional studyStatisticsComputer sciencePsychologyDiabetes mellitusMathematicsMedicineArtificial intelligenceEndocrinology

Abstract

fetched live from OpenAlex

Abstract Large language models (LLMs) have fundamentally changed how patients and clinicians retrieve information; however, it is unclear how accurate and consistent widely available LLMs are in answering questions related to medical information. Our objective was to evaluate the accuracy and consistency of ChatGPT in answering questions related to the management of type 2 diabetes mellitus (T2DM). Three users asked ChatGPT 13 questions pertaining to medications from the top five most common classes of T2DM medications. A response was labelled inconsistent if the response provided to one user differed from the response provided to at least one other user in the same domain for the same medication. A response was labelled as inaccurate if the information provided by ChatGPT was incorrect based on the most recent FDA-approved drug label, in addition to review by an expert reviewer. Additionally, one user asked ChatGPT 26 basic questions related to the management of T2DM, in which the answer was categorized as correct or incorrect. We summarized all results using descriptive statistics. ChatGPT delivered inaccurate responses in seven out of 13 domains and inconsistent responses in seven out of 13 domains for drugs in all five classes of T2DM medication. Of ChatGPT’s responses to the 26 basic T2DM treatment questions, 7 (26%) were incorrect. In this cross-sectional study, we identified that it was common for ChatGPT to provide incorrect or inconsistent responses to enquiries related to the management of type 2 diabetes.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.050
metaresearch head score (Gemma)0.177
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.050
Threshold uncertainty score0.263

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0500.177
Meta-epidemiology (narrow)0.0000.001
Meta-epidemiology (broad)0.0010.002
Bibliometrics0.0020.001
Science and technology studies0.0010.001
Scholarly communication0.0020.002
Open science0.0010.002
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.339
GPT teacher head0.534
Teacher spread0.196 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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Same venuemedRxiv→Same topicArtificial Intelligence in Healthcare and Education→French-language works237,207→