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Record W4412072032 · doi:10.1177/10668969251355208

A Mediastinal Neuroblastoma in a 31-Year-Old Woman Presenting After a Prolonged Indolent Course: A Report and Review of Literature

2025· article· en· W4412072032 on OpenAlexaff
Hiroyuki Shimada, Elizabeth Nizalik, Adam Sachs, Taniesha James-Maxwell, Bibianna Purgina

Bibliographic record

VenueInternational Journal of Surgical Pathology · 2025
Typearticle
Languageen
FieldMedicine
TopicNeuroblastoma Research and Treatments
Canadian institutionsChildren's Hospital of Eastern OntarioOttawa HospitalUniversity of Ottawa
Fundersnot available
KeywordsNeuroblastomaMedicineNeural crestPediatricsPathologyBiology

Abstract

fetched live from OpenAlex

Neuroblastomas in adults are extremely rare and are generally regarded to have poorer outcomes compared to infants and children. Due to the scarcity of data among adult patients with neuroblastoma, treatment guidelines are also not well established. These tumors are derived from primitive neural crest cells and fall under a broader category of small round blue cell tumors which can pose diagnostic challenges in atypical scenarios like adult patients or atypical primary sites. Accurate diagnosis is vital to appropriate patient management. We present one such rare occurrence of a mediastinal neuroblastoma in a 31-year-old adult woman presenting with neurological symptoms after a prolonged indolent course.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.504
Threshold uncertainty score0.350

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.336
Teacher spread0.326 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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