Renal lymphoma diagnosis via urinary cytology and PCR for antigen receptor rearrangement in a cat
Bibliographic record
Abstract
Abstract A client‐owned 8‐year‐old male neutered Norwegian Forest cat presented with suspected neurological episodes. Cellular preservation was poor on a cytocentrifuged slide of a urine sample from cystocentesis; however, low‒moderate numbers of possible variably sized lymphocytes were observed, raising concern for lymphoma. Abdominal ultrasonography revealed marked bilateral nephropathy, hydronephrosis, and severe pyelectasia. Repeated microscopic urinalysis via cystocentesis identified numerous large lymphocytes containing magenta granules, which are supportive of large granular lymphocyte lymphoma. PCR for antigen receptor rearrangements using the urine sample revealed a clonally rearranged T‐cell receptor gene, which was consistent with T‐cell neoplasia. A chemotherapy protocol consisting of vincristine, cytarabine, doxorubicin, and prednisolone was initiated; however, the patient's condition deteriorated following administration of vincristine, prompting euthanasia. Necropsy was declined by the owner.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.003 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".