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Record W4412156286 · doi:10.1152/ajpgi.00130.2025

Energy status alters intestinal function and the gut microbiota during consecutive days of high energy demands

2025· article· en· W4412156286 on OpenAlexaff
Cassandra Suther, Adrienne Hatch‐McChesney, Jillian T. Allen, Nabarun Chakraborty, Alex Lawrence, Candace Moyler, George Dimitrov, Aarti Gautam, Rasha Hammamieh, Jess A. Gwin, Lee M. Margolis, Stephen R. Hennigar, James P. McClung, Stefan M. Pasiakos, J. Philip Karl

Bibliographic record

VenueAmerican Journal of Physiology-Gastrointestinal and Liver Physiology · 2025
Typearticle
Languageen
FieldMedicine
TopicDiet and metabolism studies
Canadian institutionsGeneral Dynamics (Canada)
FundersArmed Forces Institute of Regenerative MedicineMedical Research and Materiel Command
KeywordsFunction (biology)Energy (signal processing)Gut floraEnergy metabolismMedicineBiologyInternal medicineImmunologyCell biologyMathematicsStatistics

Abstract

fetched live from OpenAlex

The effect of energy status on host-gut microbiota interactions impacting intestinal function during periods of high energy demands is unknown. Herein, increasing energy intake to prevent energy deficit during three days of high physical activity-induced energy demands prevented increases in intestinal permeability and transit time, and transiently reduced gut microbiota community richness without compromising community functional potential. Results suggest minimizing energy deficits may benefit gastrointestinal function during periods of high energy demands.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.003

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.004
GPT teacher head0.210
Teacher spread0.206 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2025
Admission routes1
Has abstractyes

Explore more

Same venueAmerican Journal of Physiology-Gastrointestinal and Liver PhysiologySame topicDiet and metabolism studiesFrench-language works237,207