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Record W4412168805 · doi:10.1139/cjm-2025-0053

Harnessing synthetic biology to empower a circular plastics economy

2025· article· en· W4412168805 on OpenAlexafffundvenue
Aaron Yip, Ida Putu Wiweka Dharmasiddhi, Brian Zubrzycki, Christian Euler, Elisabeth Prince, Yilan Liu, Brian Ingalls, Marc G. Aucoin

Bibliographic record

VenueCanadian Journal of Microbiology · 2025
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicMicrobial Metabolic Engineering and Bioproduction
Canadian institutionsUniversity of Waterloo
FundersNatural Sciences and Engineering Research Council of Canada
KeywordsCircular economySynthetic biologyPlastic wasteBiochemical engineeringSustainabilityBioprocessBiotechnologyIndustrial biotechnologyWaste managementEngineeringBiologyEcologyComputational biology

Abstract

fetched live from OpenAlex

Biotechnology offers unique opportunities for mitigating and upcycling plastic waste with low-intensity bioprocesses. Synthetic biology can further enhance bioprocesses for sustainably dealing with plastic waste and supporting a circular plastics economy. We provide an overview of current strategies for leveraging synthetic biology and microbial community engineering to degrade and upcycle plastic waste, with application to both industrial and environmental settings. We further discuss complementary strategies for pre-treating plastic materials and altering recalcitrant vinyl polymers to enhance bioprocessing efficiency. Additionally, we provide commentary on future research directions that would propel biotechnological solutions toward application in a circular plastics economy.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.004
Threshold uncertainty score0.013

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.002
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0010.001
Science and technology studies0.0010.004
Scholarly communication0.0030.005
Open science0.0010.002
Research integrity0.0020.003
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.004
GPT teacher head0.208
Teacher spread0.203 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes3
Has abstractyes

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