The impact of the <i>BmSur8</i> gene, encoding a scaffold protein, on cocoon silk yield in <i>Bombyx mori</i>
Bibliographic record
Abstract
Cocoon silk quality is a critical determinant of the economic value in the sericulture industry for Bombyx mori L. (Lepidoptera: Bombycidae). Sur8 functions as a positive regulator of the RAS-MAPK signaling cascade, which plays an essential role in regulating cocoon silk production in Bombyx mori. However, the specific functions of BmSur8 in silkworms have not been fully elucidated. In this study, we demonstrate that BmSur8 is a highly conserved gene expressed across all life stages and various tissues at the third day of the fifth instar larvae (L5D3) stage in Bombyx mori. Knockout of the BmSur8 gene results in a 15.2% reduction in silk yield in females and a 13.4% reduction in males, with the cocoon layer rate in females decreasing by 3.8%. Through transcriptomic analysis of posterior silk glands (PSGs) at L5D3 stage from ΔBmSur8 mutants and Nistari controls, as well as mass spectrometry analysis of BmSur8-interacting proteins in BmN cells, we find that BmSur8 potentially interacts with BmEtfb and regulates the expression of BmCDA and BmjunD, thereby participating in material and energy metabolism. This study provides a comprehensive analysis of the function of BmSur8 in metabolic pathways and offers theoretical insights and experimental data for researching silkworm cocoon silk quality and yield, as well as for breed selection and breeding.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".