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Record W4412354217 · doi:10.5376/cmb.2024.14.0023

Unveiling the Patterns and Impact of New Gene Recruitment in Development and Evolution

2024· article· en· W4412354217 on OpenAlexvenueno aff
Kaiwen Liang

Bibliographic record

VenueComputational Molecular Biology · 2024
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetics, Bioinformatics, and Biomedical Research
Canadian institutionsnot available
Fundersnot available
KeywordsEvolutionary biologyBiologyGeneGeneticsComputational biologyGenealogyHistory

Abstract

fetched live from OpenAlex

This study explores the critical role of new gene emergence in driving evolutionary innovation and biodiversity. The research reviews various mechanisms of new gene origin, such as gene duplication, de novo gene emergence from noncoding sequences, and the co-option of genomic elements. It focuses on how these genes are recruited into developmental pathways, leading to phenotypic changes and the evolution of complex traits, including brain development and reproductive behaviors. Using comparative genomics, studies of gene regulatory networks (GRNs), and high-throughput sequencing technologies to track gene function, the results show that new genes play a significant role in developmental innovation, adaptive evolution, and environmental adaptation. The study emphasizes the importance of new gene recruitment in understanding the dynamics of genetic networks and its broader implications for evolutionary biology. It suggests improving methods for gene identification and functional characterization, while expanding research to non-model organisms.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.001
Scholarly communication0.0010.003
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.036
GPT teacher head0.350
Teacher spread0.314 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes1
Has abstractyes

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