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Record W4412354217 · doi:10.5376/cmb.2024.14.0023

Unveiling the Patterns and Impact of New Gene Recruitment in Development and Evolution

2024· article· en· W4412354217 on OpenAlex
Kaiwen Liang

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

venuePublished in a venue whose home country is Canada.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueComputational Molecular Biology · 2024
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetics, Bioinformatics, and Biomedical Research
Canadian institutionsnot available
Fundersnot available
KeywordsEvolutionary biologyBiologyGeneGeneticsComputational biologyGenealogyHistory

Abstract

fetched live from OpenAlex

This study explores the critical role of new gene emergence in driving evolutionary innovation and biodiversity. The research reviews various mechanisms of new gene origin, such as gene duplication, de novo gene emergence from noncoding sequences, and the co-option of genomic elements. It focuses on how these genes are recruited into developmental pathways, leading to phenotypic changes and the evolution of complex traits, including brain development and reproductive behaviors. Using comparative genomics, studies of gene regulatory networks (GRNs), and high-throughput sequencing technologies to track gene function, the results show that new genes play a significant role in developmental innovation, adaptive evolution, and environmental adaptation. The study emphasizes the importance of new gene recruitment in understanding the dynamics of genetic networks and its broader implications for evolutionary biology. It suggests improving methods for gene identification and functional characterization, while expanding research to non-model organisms.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.725
Threshold uncertainty score0.245

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.036
GPT teacher head0.350
Teacher spread0.314 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it