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Record W4412391450 · doi:10.1186/s40246-025-00784-z

Communicating clearly about data sharing in genomics

2025· review· en· W4412391450 on OpenAlexaff
Donrich Thaldar, Diya Uberoi, Adrian Thorogood, Richard Milne, Ainsley J. Newson, Alison Hall, David Glazer, Paul Esselaar, Yann Joly

Bibliographic record

VenueHuman Genomics · 2025
Typereview
Languageen
FieldMedicine
TopicEthics in Clinical Research
Canadian institutionsOntario GenomicsTerry Fox Research InstituteMcGill Genome Centre
Fundersnot available
KeywordsHuman geneticsGenome BiologyGenomicsBiologyComputational biologyData sharingComputational genomicsGeneticsData scienceEvolutionary biologyComputer scienceGenomeMedicineGene

Abstract

fetched live from OpenAlex

In the field of genomics, the secure and responsible sharing of data across institutions and borders is critical for advancing research and improving healthcare. However, challenges such as inconsistent terminology, data localization requirements, and cross-border data transfer regulations impede collaboration and innovation. To address these barriers, the Global Alliance for Genomics and Health (GA4GH), a global standards-setting organization in genomics, has developed a standardized lexicon of key terms for data sharing, including the nascent terms data visiting and federated data analysis. These definitions aim to improve communication within the genomics community by ensuring a consistent understanding of complex processes, addressing challenges like data localization and cross-border transfer. This article introduces these recently developed data sharing-related terms and considers their implications for data governance and global health research.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.033
metaresearch head score (Gemma)0.042
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Open science
Consensus categoriesnone
DomainCandidate signal: Reproducibility · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.998
Threshold uncertainty score0.173

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0330.042
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0030.004
Science and technology studies0.0010.009
Scholarly communication0.0060.010
Open science0.0020.005
Research integrity0.0060.009
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.846
GPT teacher head0.664
Teacher spread0.183 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
DomainReproducibility
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2025
Admission routes1
Has abstractyes

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