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Record W4412402666 · doi:10.1101/2025.07.11.25331394

Physical activity and cardiometabolic health across an extreme lifestyle gradient

2025· preprint· en· W4412402666 on OpenAlexaff
Thomas S. Kraft, Ian J. Wallace, Yvonne Ai Lian Lim, Kar Lye Tam, Tan Bee Ting A P Tan Boon Huat, Robert L. Tennyson, Steven K. W. Chow, Kamal Solhaimi Fadzil, Colin Nicholas, Izandis bin Mohd Sayed, Vivek V. Venkataraman, Amanda J. Lea

Bibliographic record

VenuemedRxiv · 2025
Typepreprint
Languageen
FieldMedicine
TopicCardiovascular Health and Risk Factors
Canadian institutionsUniversity of Calgary
FundersNational Science Foundation
KeywordsPhysical activityEnvironmental healthGeographyMedicinePhysical medicine and rehabilitation

Abstract

fetched live from OpenAlex

Cardiometabolic diseases commonly rise with market-integration, industrialization, and urbanization, yet the direct role of physical activity remains debated. We collected accelerometry, health, and interview data from 1075 Orang Asli adults in Peninsular Malaysia, who currently span a wide range from rural, non-industrial to urban, industrialized lifestyles. More urban lifestyles were associated with reduced physical activity and worse cardiometabolic health. However, physical activity mediated only a small portion of urbanization's effects, suggesting independent influences. Age-related declines in activity were steeper in urban settings, indicating that non-industrial lifestyles promote activity in old age and may buffer older adults from functional decline. These results support the view that declining physical activity is an evolutionarily novel challenge contributing to poor health in modern environments.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.552
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.046
GPT teacher head0.365
Teacher spread0.319 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2025
Admission routes1
Has abstractyes

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