Thermally stable, photocrossinkable and biocompatible copolymers for melt electrowriting
Bibliographic record
Abstract
-caprolactone), is prone to creep under dynamic loads and plasticization due to water absorption, making its use problematic for situations demanding dynamic loading in aqueous media. Photocrosslinking during processing can eliminate these problems while also allowing for manipulation of mechanical properties. However, photocrosslinking strategies utilized to date have either limited processing time or require prolonged UV irradiation. Herein we demonstrate the potential of a cyclic trimethylene carbonate monomer bearing a pendant coumarin moiety (MUM) for creating MEW processable copolymers that are thermally stable and photocrosslinkable. The MUM was copolymerized with caprolactone to form copolymers that were MEW processed into both linear and crimped fiber structures followed by long-wave UV photocrosslinking yielding high modulus scaffolds with very low sol content. The photocrosslinked scaffolds were also cytocompatible. The ability to copolymerize MUM with other cyclic lactone monomers allows for the generation of a variety of MEW processable polymers with tunable properties. Collectively, the findings demonstrate the potential of MUM containing copolymers for MEW generation of scaffolds for a range of tissue engineering applications.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".