Association of plasma BMP6 levels with the rates of brain atrophy in older people without dementia
Bibliographic record
Abstract
Background: Bone morphogenetic protein 6 (BMP6) has been implicated in the pathogenesis of Alzheimer's disease (AD), and its levels have been reported to be associated with cognitive performance. However, few studies have examined the association between plasma BMP6 levels and brain atrophy in older adults. Methods: A total of 340 older adults without dementia were included in the current study. Study participants had baseline plasma BMP6 data available and at least two structural MRI scans. Volumes of six brain regions were measured, including the hippocampus, entorhinal cortex, middle temporal gyrus, fusiform gyrus, ventricles, and whole brain. A series of linear mixed-effects models were built to examine the associations of plasma BMP6 levels with brain atrophy over time. Results: Our study revealed that higher plasma BMP6 levels were associated with a reduced rate of volume loss in the hippocampus, entorhinal cortex, middle temporal gyrus, and whole brain. However, there was no significant link between plasma BMP6 levels and changes in the volume of the fusiform gyrus or ventricles. Conclusion: Our results may provide novel insights into the mechanisms of neurodegeneration in AD, contributing to new avenues for timely intervention and potentially slowing disease progression.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".