Flail Tricuspid and Mitral Valve in Neonatal Lupus
Bibliographic record
Abstract
BACKGROUND: Neonatal lupus erythematosus (NLE) typically presents as congenital heart block; flail atrioventricular valve leaflets is especially rare. CASE SUMMARY: A neonate with flail tricuspid and mitral valve resulted in severe atrioventricular valve insufficiency. There were high anti-Ro60 antibody titers consistent with NLE. Steroids and immunoglobulins were administered. Mitral and tricuspid valve repairs were undertaken. An inability to wean from extracorporeal membrane oxygenation led to the mitral valve being replaced with a modified Melody valve and then mechanical mitral valve. DISCUSSION: This is the first reported case of NLE presenting with bilateral atrioventricular valve chordal rupture, necessitating early valve replacement. This highlights a severe manifestation of NLE and has implications for diagnosis, surveillance, and novel management strategies. TAKE-HOME MESSAGES: NLE can present with atypical, life-threatening valvular pathology of both the tricuspid and mitral valve. The Melody valve offers a promising bridge to a definitive valve replacement in the mitral position.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".