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Associations of transition cow metabolism with subsequent manifestation and intensity of estrous behavior in cyclic cows

2025· article· en· W4412594985 on OpenAlexafffund
A.M.L. Madureira, Chantel Van Dorp, Guilherme Madureira, B. Mion, Olivia Chiu, T.A. Burnett, José Felipe Warmling Sprícigo, E.S. Ribeiro

Bibliographic record

VenueTheriogenology · 2025
Typearticle
Languageen
FieldAgricultural and Biological Sciences
TopicReproductive Physiology in Livestock
Canadian institutionsUniversity of Guelph
FundersNatural Sciences and Engineering Research Council of CanadaOntario Ministry of Agriculture, Food and Rural AffairsDairy Farmers of OntarioCanada First Research Excellence FundUniversity of Guelph
KeywordsEstrous cycleAnimal scienceTransition (genetics)MetabolismChemistryInternal medicineEndocrinologyBiologyMedicineBiochemistry

Abstract

fetched live from OpenAlex

This retrospective cohort study investigated the associations between transition cow metabolism and estrous behavior in 226 cyclic Holstein cows. Body weight, feed intake, and milk yield were monitored to calculate energy balance. Blood samples were collected on days −21, −14, −10, −7, −3, 0, 3, 7, 10, 14, 21, and 65 relative to calving. Following the second PGF 2α injection of a Presynch program, cows were monitored for estrous behavior over an 11-day period using activity sensors. Estrus duration, peak activity, and area under the curve (AUC) were calculated from raw activity data. Cows not detected in estrus were grouped as no increase in activity (NIA; n = 90). Those detected in estrus were classified based on AUC as below (moderate increase in activity or MIA; n = 68) or above (large increase in activity or LIA; n = 68) the median. By design, AUC was 147 % greater, peak was 67 % higher, and duration was 74 % longer in LIA compared with MIA cows. Compared with NIA, cows that expressed estrus had higher body condition and lower serum concentrations of nonesterified fatty acids (NEFA; 0.43 vs. 0.49 ± 0.02 mmol/L), ceruloplasmin (49.9 vs. 52.9 ± 1.0 mg/L), superoxide dismutase (2.06 vs. 2.28 ± 0.06 U/mL), and peak haptoglobin. Among cows that expressed estrus, metabolic differences during the transition were limited to higher NEFA in LIA than in MIA cows (0.46 vs. 0.40 ± 0.02 mmol/L). These findings indicate that transition metabolism may influence the subsequent manifestation of estrous behavior in cyclic cows. • Manifestation of estrus in cyclic cows was linked to previous transition metabolism. • Characteristics of estrous behavior were not associated with transition metabolism. • Improved transition management may enhance estrus detection in cyclic cows. • Peak activity and duration of estrus showed only a moderate positive correlation. • The proposed AUC was highly correlated with both peak activity and duration of estrus.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.914
Threshold uncertainty score0.154

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.023
GPT teacher head0.247
Teacher spread0.225 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes2
Has abstractyes

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