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Record W4412670258 · doi:10.1007/s00421-025-05910-2

Moderate heart rate-matched hypoxic exercise: autonomic and cardiovascular responses to different degrees of hypoxic stress

2025· article· en· W4412670258 on OpenAlexaff
Alessandro Fornasiero, Alicia González-Represas, Andrea Zignoli, Federico Stella, Mark Rakobowchuk, Laurent Mourot

Bibliographic record

VenueEuropean Journal of Applied Physiology · 2025
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicHigh Altitude and Hypoxia
Canadian institutionsThompson Rivers University
FundersUniversité de Franche-ComtéUniversità degli Studi di VeronaUniversidade de Vigo
KeywordsMedicineHeart rateBlood pressureBaroreflexCardiologyInternal medicineStroke volumeHeart rate variabilityHypoxia (environmental)Cardiac outputHemodynamicsAnesthesiaOxygen

Abstract

fetched live from OpenAlex

Abstract Purpose This study aims to assess the impact of HR-matched exercises under varying hypoxic stress levels on exercise and post-exercise autonomic and cardiovascular responses. Methods Twelve moderately aerobically trained healthy men (mean age: 23 ± 2 years, height: 179 ± 8 cm, weight: 71.2 ± 9.9 kg, BMI: 22.2 ± 2.2 kg/m 2 , VO 2 max: 53.1 ± 4.2 mL/min/kg) completed an interval exercise session at 75% of their normoxic maximum heart rate (75%HRmax) under three hypoxic conditions: FiO 2 = 16.2% (2000 m a.s.l; H16), FiO 2 = 14.3% (3000 m a.s.l; H14), and FiO 2 = 12.6% (4000 m a.s.l; H12). Each session included 5 min of seated rest, a 5-min sub-maximal load warm-up, and five 5-min work intervals with 1-min passive recovery periods. Results During hypoxic exercise, RMSSD decreased significantly following the first bout coinciding with an increase in heart rate. The RMSSD increase during 60-s recovery intervals was significantly lower after the 4th and 5th bouts compared to the 1st and 2nd bouts ( p < 0.05). At 15 min post-exercise, mean RR, systolic blood pressure and stroke volume decreased. No changes were observed in cardiac output or baroreflex sensitivity. At 60 min post-exercise, SDNN, RMSSD, mean arterial pressure and diastolic blood pressure increased significantly compared to 15 min post-exercise. No condition or interaction differences were found. Conclusion Despite the decreased oxygen saturation with increased hypoxia levels, HR-matched interval exercise induced similar cardiac and autonomic responses across all hypoxic conditions. Baseline cardiac autonomic function and hemodynamics recovered within 60 min with no impact of hypoxia on baroreflex sensitivity.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.005

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.226
Teacher spread0.216 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

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