Radiation Therapy for Primary Cutaneous Rosai-Dorfman Disease of the Face: A Case Report Resistant to Multiple Lines of Treatment and a Literature Review
Bibliographic record
Abstract
Rosai-Dorfman disease (RDD) is a rare subtype of sinus histiocytosis, with primary cutaneous RDD (PCRDD) being an even rarer form, characterized by cutaneous lesions without systemic involvement. PCRDD presents a significant diagnostic challenge and is often resistant to conventional therapies, including surgical resection, steroids, and chemotherapy. Currently, no established management guidelines exist for this condition. Radiation therapy is emerging as a promising treatment option, especially for refractory cases involving cosmetically sensitive or difficult-to-resect areas. This case report presents a patient with treatment-resistant PCRDD affecting the face, which was refractory to multiple therapeutic approaches, including chemotherapy. The patient achieved durable remission with radiation therapy at an 18-month follow-up, highlighting the efficacy of this modality in managing resistant PCRDD and the importance of a multidisciplinary approach.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".