EOAI3402143 inhibits lung adenocarcinoma progression through the NF-κB/NR4A1 pathway
Bibliographic record
Abstract
<p indent="0mm">Lung adenocarcinoma (LUAD) is currently the cancer with the highest morbidity and mortality rates in the world, and its targeted therapy, although effective, is limited in the types of targeted drugs and prone to drug resistance in treated patients. Therefore, the continuous discovery of new targeted therapeutic agents is particularly crucial for the treatment of LUAD. Here, we aim to investigate the antitumor effect of EOAI3402143 on LUAD and the potential mechanism of its action. We use flow cytometry to analyze apoptosis, transwell and colony formation assays to detect cell migration, invasion and proliferation ability; western blot, RT-qPCR and RNA-seq to analyze the signaling pathways involved in EOAI3402143; and in vivo experiments to test the therapeutic effect of EOAI3402143 on LUAD. Our results show that EOAI3402143 promotes apoptosis and inhibits the migration, invasion and proliferation of LUAD cells. Mechanistic studies reveal that EOAI3402143 inhibits the activation of the NF-κB pathway and suppresses the expression of NR4A1, which in turn inhibits the progression of LUAD. <italic>In vivo</italic> experiments revealed that EOAI3402143 has a better therapeutic effect on LUAD. These findings indicate that EOAI3402143 has significant antitumor efficacy against LUAD and is promising as a new therapeutic agent for LUAD.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".