Adverse Cardiovascular Events Are Infrequent but Significantly Associated With Systolic and Pre-Systolic Hypertension: An Occupational Cohort Study
Bibliographic record
Abstract
Background: Cardiovascular diseases (CVDs) remain the leading cause of global mortality. Different blood pressure subtypes may have varying associations with cardiovascular events, but evidence remains inconclusive in the working population. The objective of the study was to evaluate the incidence and differences between hypertension and prehypertension subtypes in the development of cardiovascular events in an occupational cohort. Methods: A retrospective cohort study including 12,027 workers monitored over 8 years. The outcome variable was the development of CVD, including myocardial infarction and/or stroke. Hypertension subtypes were classified as normotension (systolic blood pressure (SBP) < 140 mm Hg and diastolic blood pressure (DBP) < 90 mm Hg), isolated systolic hypertension (SBP ≥ 140 mm Hg and DBP < 90 mm Hg), isolated diastolic hypertension (SBP < 140 mm Hg and DBP ≥ 90 mm Hg), and systolic-diastolic hypertension (SBP ≥ 140 mm Hg and DBP ≥ 90 mm Hg). Prehypertension subtypes were defined as isolated systolic prehypertension (SBP 120 - 139 mm Hg and DBP < 80 mm Hg), isolated diastolic prehypertension (SBP < 120 mm Hg and DBP 80 - 89 mm Hg), and systolic-diastolic prehypertension (SBP 120 - 139 mm Hg and DBP 80 - 89 mm Hg). Cox models were used to estimate crude hazard ratios (cHRs) and adjusted hazard ratios (aHRs), controlling for sociodemographic variables and cardiovascular risk factors. Results: Isolated systolic hypertension (aHR: 6.78, 95% confidence interval (CI): 3.10 - 14.8) and isolated systolic prehypertension (aHR: 3.42, 95% CI: 1.73 - 6.74) showed significant associations with cardiovascular events, even after adjusting for confounding variables. Neither isolated diastolic nor systolic-diastolic prehypertension and hypertension showed significant associations. Conclusions: While cardiovascular events were infrequent in this occupational cohort, those that occurred showed significant associations with both systolic hypertension and pre-systolic hypertension, suggesting the importance of systolic pressure monitoring in workplace health surveillance.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.001 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".