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Record W4412774196 · doi:10.1016/j.tins.2025.06.003

Integrating and interpreting brain maps

2025· review· en· W4412774196 on OpenAlexafffund
Justine Y. Hansen, Bratislav Mišić

Bibliographic record

VenueTrends in Neurosciences · 2025
Typereview
Languageen
FieldNeuroscience
TopicFunctional Brain Connectivity Studies
Canadian institutionsMcGill UniversityMontreal Neurological Institute and Hospital
FundersFonds de recherche du Québec – Nature et technologiesCanadian Institutes of Health ResearchFondation Brain CanadaNatural Sciences and Engineering Research Council of CanadaCanada Research ChairsMichael J. Fox Foundation for Parkinson's Research
KeywordsPsychologyNeuroscienceCognitive scienceCognitive psychology

Abstract

fetched live from OpenAlex

Tangled molecular, cellular, and dynamic undercurrents shape brain organization. An emerging paradigm across neuroscience domains is to comprehensively measure the spatial patterning of multiple biological features, yielding precise brain maps. How can these features be conceptually integrated into a coherent understanding of brain structure and function? Here we review the methodology and practice of interpreting relationships between maps of biological features. We demonstrate how neuroscience can increasingly be approached as a data science, complete with detailed multiomic datasets, tools for representing diverse data types, and an extensive repertoire of analytics. We also outline methodological and conceptual challenges for disentangling relationships among brain maps. Ultimately, studying the brain from an integrative perspective changes the nature of scientific questions that can be asked, as well as the culture and conduct of scientific inquiry.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.036
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.994
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.036
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.003
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.085
GPT teacher head0.384
Teacher spread0.299 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designOther design
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations14
Published2025
Admission routes2
Has abstractyes

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