Leptomeningeal carcinomatosis presenting as catatonia
Bibliographic record
Abstract
Lung cancer is a common cause of cancer deaths worldwide. Cancer molecular profiling of somatic mutations in lung cancer helps both predict the underlying biology and identify therapeutic targets. c-ROS proto-oncogene 1 receptor tyrosine kinase ( ROS1 ) rearranged lung cancer is a rare molecular subtype of lung cancer that is associated with central nervous system metastases and amenable to targeted therapy. We present a case of a patient with metastatic non-small cell lung cancer with a ROS1 rearrangement who acutely presented with catatonia while on targeted treatment. A full diagnostic workup revealed that the acute decline was secondary to leptomeningeal carcinomatosis (LMC). This case report describes the diagnostic workup for this atypical presentation of LMC and the subsequent treatment strategies. This case challenges the traditional paradigm that patients admitted with cancer-related decline are not candidates for systemic therapy and highlights the key role of collaboration with the oncology team.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".