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Record W4412790473 · doi:10.1016/j.cub.2025.07.010

Chitooligosaccharide receptors modulate root microbiota to enhance symbiosis and growth in Medicago

2025· article· en· W4412790473 on OpenAlexfundno aff
Jing-Mei Qian, Kangping Li, Weidong Liu, Jingyi Zhang, A.R.G. Wylie, Brian Arnall, Mark J. Krzmarzick, Ertao Wang, Giles Oldroyd, Yang Bai, Feng Feng, Jingying Zhang

Bibliographic record

VenueCurrent Biology · 2025
Typearticle
Languageen
FieldAgricultural and Biological Sciences
TopicLegume Nitrogen Fixing Symbiosis
Canadian institutionsnot available
FundersNational Key Research and Development Program of ChinaCanadian Anesthesiologists' SocietyChina Academy of Chinese Medical SciencesMax-Planck-GesellschaftChinese Academy of SciencesNational Natural Science Foundation of China
KeywordsBiologySymbiosisReceptorMedicagoCell biologyEcologyMicrobiologyBacteriaGeneticsGene

Abstract

fetched live from OpenAlex

Plant roots interact with beneficial microbes, such as arbuscular mycorrhizal fungi (AMF), to aid in nutrient uptake. The interaction with AMF is initiated by plant Lysin motif (LysM) receptor-like kinases, CERK1 and LYR4 in Medicago truncatula, that detect AMF signals such as chitooligosaccharides (COs). However, the broader role of AMF-detecting receptors in shaping the root microbial community is largely unknown, and the impact of these receptor-mediated microbial communities on the AMF symbiosis is yet to be determined. This study examines the effects of CERK1 and LYR4 mutations on the root bacterial community, showing that these receptors have significant effects on shaping the bacterial community. Using bacteria isolated from wild-type roots, we created a synthetic bacterial community (SynCom), CO-SynCom. Plants inoculated with CO-SynCom exhibited significantly enhanced growth and AMF colonization in a manner dependent on the CO receptors LYR4 and CERK1, likely due to CERK1- and LYR4-mediated changes in hormone-related pathways and activation of symbiosis signaling. Our results highlight the essential role of plant symbiotic receptors in shaping root microbiota and offer valuable insights into optimizing plant-microbe interactions to enhance symbiosis and support sustainable agriculture.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.002

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.265
Teacher spread0.255 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2025
Admission routes1
Has abstractyes

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