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Record W4412796434 · doi:10.1038/s41467-025-62218-7

Biomarker panels for improved risk prediction and enhanced biological insights in patients with atrial fibrillation

2025· article· en· W4412796434 on OpenAlexafffund
Pascal Meyre, Stefanie Aeschbacher, Steffen Blum, Tobias Reichlin, Moa Lina Haller, Nicolas Rodondi, Andreas S. Müller, Alain Bernheim, Jürg H. Beer, Giorgio Moschovitis, André Ziegler, Bianca Wahrenberger, Elia Rigamonti, Giulio Conte, Philipp Krisai, Leo H. Bonati, Stefan Osswald, Michael Kühne, David Conen

Bibliographic record

VenueNature Communications · 2025
Typearticle
Languageen
FieldMedicine
TopicGDF15 and Related Biomarkers
Canadian institutionsImpactMcMaster UniversityPopulation Health Research Institute
FundersDaiichi Sankyo EuropeMicroPortMach-Gaensslen Foundation of CanadaBiosense WebsterSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungFoundation for Cardiovascular ResearchSchweizerische HerzstiftungUniversität BaselAstraZenecaPfizerBoston Scientific CorporationNational Science Foundation
KeywordsMedicineBiomarkerAtrial fibrillationInternal medicineNatriuretic peptideHeart failureMyocardial infarctionGDF15CardiologyTroponinStroke (engine)Brain natriuretic peptideBioinformatics

Abstract

fetched live from OpenAlex

OpenAlex records an abstract for this work, but it could not be fetched just now.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.054
Threshold uncertainty score0.349

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.282
Teacher spread0.269 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations6
Published2025
Admission routes2
Has abstractyes

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