Bibliographic record
Abstract
Transfusion-associated graft-versus-host disease (TA-GVHD) is a rare but often fatal complication of allogeneic transfusion, caused by the activation and expansion of donor T lymphocytes in susceptible recipients. Prevention focuses on reducing these immune cells through leukoreduction and irradiation. While leukoreduction of blood components decreases white blood cell content and improves overall transfusion safety, it does not fully prevent TA-GVHD, as viable T cells may persist. Irradiation using gamma or X-ray methods remain the most effective strategy, inactivating donor T cells by inducing DNA damage and suppressing proliferation. However, it also compromises red blood cell quality by increasing hemolysis, oxidative injury, membrane damage, extracellular potassium, and reducing storage duration. As an alternative, hypothermic storage of leukoreduced red blood cells is gaining attention. Evidence suggests that extending storage beyond 21 days significantly reduces T cell viability and proliferation without compromising red blood cell integrity. Further research is needed to directly compare the efficacy of hypothermic storage to irradiation.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.003 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".