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Validation of clinical ratings of cervical dystonia using computer-generated avatars

2025· article· en· W4412798960 on OpenAlexaboutno aff
Sebastian Loens, Roland Stenger, Feline Hamami, Alexander Münchau, Theresa Paulus, Anne Weißbach, Gesine Marie Sallandt, Tatiana Usnich, Max Borsche, Martje G. Pauly, Lara M. Lange, Markus A. Hobert, Rebecca Herzog, Ana Luísa de Almeida Marcelino, Tina Mainka, Friederike Borngräber, Lukas L. Goede, Kirsten E. Zeuner, Julienne Haas, Jos Becktepe, Alexander Baumann, Robin Wolke, Chi Wang Ip, Thorsten Odorfer, Daniel Zeller, Lisa Rauschenberger, John‐Ih Lee, A Philipp, Petyo Nikolov, Tristan Kölsche, Joachim K. Krauss, Johanna Nagel, Joachim Runge, Jessica Utermarck, Katja Kollewe, Johanna Doll‐Lee, Johanne Heine, Linda Veith Sanches, Simone Zittel, Kai Grimm, Paweł Tacik, André Dong Lee, Andrea Henze, Sebastian Fudickar, Tobias Bäumer

Bibliographic record

VenueParkinsonism & Related Disorders · 2025
Typearticle
Languageen
FieldMedicine
TopicBotulinum Toxin and Related Neurological Disorders
Canadian institutionsnot available
Fundersnot available
KeywordsCervical dystoniaDystoniaPhysical medicine and rehabilitationMedicineComputer sciencePsychologyNeuroscience

Abstract

fetched live from OpenAlex

INTRODUCTION: The Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) and the Collum-Caput (Col-Cap) concept are tools for clinically assessing cervical dystonia severity. However, the accuracy of human ratings using these scales has not been systematically evaluated due to the lack of objective reference measurements. This study aims to assess and compare the accuracy of human TWSTRS and Col-Cap ratings to evaluate their robustness for clinical and research applications. METHODS: One hundred pictures of 26 avatars mimicking cervical dystonia were created using the Rocketbox Avatar library. Forty-one movement disorder specialists rated the head and neck positioning of the avatars using either TWSTRS or Col-Cap. Movements were defined around two rotational levels (head, neck) in three rotational axes (pitch, yaw, roll). RESULTS: Ratings of angular deviations showed a mean absolute error of 5.8° (SD = 7.0). Rating accuracy was primarily influenced by the magnitude of angular deviation, with larger angles leading to greater estimation errors. Direct comparison of the rating scales revealed a higher accuracy through Col-Cap ratings (71 % vs. 63 % for TWSTRS). Years of clinical experience did not significantly affect rating accuracy. CONCLUSIONS: Both rating systems (TWSTRS and Col-Cap) show moderate accuracy in assessing head and neck positioning from computer-generated avatars, with Col-Cap showing slightly higher overall accuracy but struggling with precise differentiation between head and neck movements. These findings underscore the limitations of current clinical rating scales and highlight the need for more objective, reliable tools to effectively assess cervical dystonia.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.007
metaresearch head score (Gemma)0.036
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.007
Threshold uncertainty score0.039

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0070.036
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0010.000
Science and technology studies0.0000.001
Scholarly communication0.0010.000
Open science0.0010.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.027
GPT teacher head0.333
Teacher spread0.306 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations1
Published2025
Admission routes1
Has abstractyes

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