Unraveling trauma memory: Differential functional connectivity profiles of anterior and posterior hippocampus in post-traumatic stress disorder and its dissociative subtype
Bibliographic record
Abstract
Post-traumatic stress disorder (PTSD) has long been viewed by many as a disorder of memory. Consequently, the hippocampal brain networks have been an important focus of research on the neural circuitry of PTSD given its core involvement in episodic memory and mechanisms underlying traumatic memory. The primate hippocampus is functionally divided along its long axis into the anterior (aHipp) and posterior parts (pHipp), with the anterior portion playing a greater role in emotion-related memories, while the posterior region is more involved in cognitive and spatial processing. This suggests that the aHipp may be more actively involved in PTSD. Critically, however, little research has investigated the differential involvement of these hippocampal subregions in PTSD, and most research in this area has been conducted during rest rather than during the active recall of traumatic or extremely emotional memories. It is an open question whether anterior and posterior hippocampal regions might play differential roles during trauma-related memory recall. Here, we addressed this question by investigating the activity and the whole-brain functional connectivity of the aHipp and pHipp during the recall of traumatic/moral injury (MI) related trauma memories versus neutral memories in three groups: those with PTSD without dissociative symptoms, referred to as PTSD (DS-; n = 49), those with the dissociative subtype, referred to as PTSD (DS+; n = 19), and trauma-exposed healthy controls (n = 36). Both anterior and posterior hippocampal subregions displayed abnormal functional connectivity with various brain regions in PTSD (DS+) during trauma memory recall, with the pHipp showing more extensive abnormalities compared to the anterior part. For example, the pHipp showed abnormal functional connectivity with areas such as the anterior cerebellum, the parahippocampal and fusiform gyri, sensorimotor cortex, and early visual areas of the occipital lobe in PTSD (DS+) compared to PTSD (DS-) and controls during the recall of traumatic/MI memories. Collectively, these results suggest differential involvement of the anterior and posterior hippocampus in the recall of traumatic memories in traumatic/MI-related PTSD and its dissociative subtype, which may relate to the decontextualized and fragmented nature of traumatic memories.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".