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Record W4412830562 · doi:10.1101/2025.07.29.667458

A niche construction-based perspective on chemical evolution before replication and reproduction

2025· preprint· en· W4412830562 on OpenAlexaff
François Papale, Yuri Kulish, Joseph P. Bielawski, Louis‐Patrick Haraoui

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2025
Typepreprint
Languageen
FieldPhysics and Astronomy
TopicOrigins and Evolution of Life
Canadian institutionsCentre Intégré de Santé et de Services Sociaux des LaurentidesUniversité de SherbrookeDalhousie UniversityCentre intégré de santé et de services sociaux de Chaudière-AppalachesMcGill UniversityHôpital Charles-Le MoyneCanadian Institute for Advanced Research
Fundersnot available
KeywordsNicheReplication (statistics)Niche constructionPerspective (graphical)ReproductionEvolutionary biologyBiologyComputer scienceEcologyArtificial intelligence

Abstract

fetched live from OpenAlex

Abstract Conceptual analysis has, in the past decades, established that evolution by natural selection (ENS) can occur without reproduction (1–6). This theoretical advancement has significant imports for research on the origins of life that have yet to be explored. In this paper, we introduce and defend a niche construction-based account of evolution by natural selection without reproduction (ENSwR, pronounced like “answer”), which leads to three insights regarding Darwinian evolution at the origins of life. First, we show through ENSwR the plausibility of Darwinian evolution in the prebiotic world; second, ENSwR provides a novel explanatory framework that supports origins of life theories in which autocatalytic sets of chemical reactions play a central role; third, we argue that inorganic catalytic molecules (rather than autocatalytic sets (7–9)) are relevant units of selection to understand the origins of life prior to reproduction and replication. This third argument is especially important for the field, as it helps bridge the gap between chemical and biological evolution (10).

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.684
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.235
Teacher spread0.227 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

Explore more

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