Unusual Electrophoretic Pattern in a Dog Infected With <i>Angiostrongylus vasorum</i>
Bibliographic record
Abstract
A 7-year-old female intact pug was presented for a six-month history of cough, dyspnea, and exercise intolerance. Treatment with fenbendazole was initiated 3 days before referral based on a positive blood quantitative PCR for Angiostrongylus vasorum (A. vasorum) without improvement of the clinical signs. The dog lived in Belgium with a traveling history to Corsica and Canada. On physical examination, the dog was tachypneic with expiratory dyspnea. Mild non-regenerative anemia, monocytosis, eosinophilia, and basophilia were identified on hematology. Biochemistry revealed hyperproteinemia due to hyperglobulinemia. The protein capillary zone electrophoresis (CZE) identified a restricted polyclonal (or oligoclonal) peak in the beta-globulin region and a tall and narrow peak in the gamma-globulin region, suggestive of either restricted polyclonal or monoclonal gammopathy. Further diagnostic investigations included thoracic radiographs, echocardiography, abdominal ultrasound, urinalysis, snap test 4Dx, Leishmania spp. serology, and Leishmania spp. PCR on bone marrow aspirates. Severe proteinuria was noted with a urine protein to creatinine ratio (UPCR) of 7.54. No infectious agents other than A. vasorum were identified. Treatment with fenbendazole was pursued for 7 days, followed by a spot-on application of imidacloprid/moxidectin combined with tapering the anti-inflammatory dose of steroids, with complete resolution of the respiratory signs. At 1-month recheck, hyperglobulinemia and proteinuria completely resolved, and the thoracic radiographic images improved. To the authors' knowledge, this case is the first to describe such a gammopathy associated with chronic angiostrongylosis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".